<p>Jinten hitam (<em>Nigella sativa</em>) mengandung senyawa timokuinon yang berefek sebagai imunostimulan. Ekstrak jinten hitam dikembangkan menjadi SNEDDS (<em>Self-nanoemulsifying Drug Delivery System</em>) karena masalah kelarutan. Penelitian dilakukan untuk mengetahui karakteristik SNEDDS ekstrak jinten hitam yang meliputi viskositas, ukuran tetesan nanoemulsi, <em>extract loading</em>, dan stabilitas. Pengujian aktivitas imunostimulan SNEDDS meliputi rasio sel makrofag dan indeks fagositosis.</p><p>SNEDDS ekstrak jinten hitam dioptimasi dengan metode <em>Simplex Lattice Design</em> menggunakan <em>Design Expert 7.1.5., </em>selanjutnya SNEDDS optimal diuji ukuran tetesan nanoemulsi dan zeta potensial, viskositas, serta uji stabilitas. Uji aktivitas imunostimulan dilakukan dengan metode <em>biolatex assay</em> terhadap tikus <em>Sprague Dawley</em> sebanyak 5 tikus/kelompok selama 15 hari dengan pemberian satu kali sehari yaitu kontrol positif (ekstrak meniran 7,2 mg/tikus), kelompok perlakuan yaitu ekstrak jinten hitam dengan dosis 200 mg/kgBB serta SNEDDS ekstrak jinten hitam (200 mg/kgBB), kelompok plasebo berupa formula SNEDDS tanpa ekstrak jinten hitam, dan kontrol normal, selanjutnya dihitung rasio dan indeks fagositosis makrofag.</p>SNEDDS ekstrak jinten hitam optimal mengandung 15% minyak ikan hiu cucut botol, 67,344% surfaktan (10,102% croduret 50 ss dan 57,242% tween 80), 17,656% PEG 400 sebagai ko-surfaktan dengan hasil ukuran tetesan nanoemulsi 16,3 nm, PI sebesar 0,202, zeta potensial -43,5 mV, dan viskositas antara 234,69 – 255,71 cP. Hasil <em>extract loading</em> sistem SNEDDS mencapai 600 mg ekstrak/g sistem. SNEDDS stabil setelah penyimpanan selama 90 hari pada suhu kamar dan uji <em>freeze-thawing</em>. SNEDDS ekstrak jinten hitam dengan dosis 200 mg/kgBB dapat meningkatkan rasio sel makrofag dan indeks fagositosis dibandingkan dengan ekstrak jinten tanpa formulasi (P<0,05).
Stunting telah menjadi masalah kesehatan nasional sekaligus prioritas kesehatan global yang mampu mempengaruhi kualitas Sumber Daya Manusia (SDM) sebagai generasi masa depan bangsa Indonesia. Oleh sebab diperlukan upaya penanganan masalah stunting seperti peningkatan komunikasi perubahan perilaku melalui kegiatan pengabdian masyarakat (PKM) berupa edukasi mengenai stunting sebagai salah satu perwujudan strategi penurunan stunting sesuai Peraturan Persiden Nomor 72 Tahun 2021 tentang percepatan penurunan stunting di Indonesia. Tujuan PKM ini memberikan edukasi kepada masyarakat mengenai pemberian suplemen vitamin A, Iodium, Zink, dan Zat Besi sebagai upaya perwujudan program pencegahan stunting untuk mempercepat penurunan angka stunting. Kegiatan ini dilakukan pada tanggal 16 April 2022. Kegiatan ini dilakukan saat pandemi COVID-19 sehingga mewajibkan kebijakan pertemuan secara daring. Tahap kegiatan ini meliputi persiapan, pelaksanaan, dan evaluasi. Tahap persiapan dimulai dari penyusunan materi dalam bentuk power point, video, dan poster. Tahap Pelaksanaan berupa pre-test, pemaparan materi, sesi diskusi/Tanya jawab, post-test, dan pemberian reward (penghargaan) bagi peserta terbaik. Semua kegiatan dilaksanakan secara daring (online) melalui aplikasi zoom meeting. Target peserta antara lain Institusi pendidikan, Pemerintahan, siswa-siswi SMA/SMK, masyarakat umum, dan praktisi kesehatan. Tahap evaluasi dilakukan menganalisis semua data secara deskriptif mengenai jumlah peserta, asal peserta, nilai pre-test dan post test. Hasil kegiatan ini antara lain jumlah peserta yang mengikuti PKM sebanyak 60 dengan peserta sebanyak 96% berasal dari Jawa Barat (Bekasi). Rata-rata nilai pre-test ke post-test meningkat dari 62 menjadi 83 atau mengalami peningkatan sebesar 55 %. Kesimpulan PKM ini adalah masyarakat mampu memahami materi edukasi yang dibuktikan dengan ketepatan menjawab pertanyaan seperti fungsi, dampak, sumber, dan dosis pemberian vitamin A, Zink, Iodium, dan zat Besi untuk mencegah potensi stunting. Stunting has become a national health problem as well as a global health priority that can affect the quality of Human Resources for the future generation of the Indonesian nation. Therefore, efforts to tackle stunting problems are needed, such as increasing behavior change communication through community service activities in the form of education about stunting as a manifestation of stunting reduction strategies according to Presidential Regulation Number 72 of 2021 concerning the acceleration of stunting reduction in Indonesia. The purpose of this PKM is to provide education to the public regarding the provision of vitamin A, Iodine, Zinc, and Iron supplements as an effort to realize the stunting prevention program to accelerate the reduction of stunting rates. This activity was carried out on April 16, 2022. This activity was carried out during the COVID-19 pandemic, thus requiring an online meeting policy. This activity stage includes preparation, implementation, and evaluation. The preparation stage begins with the preparation of materials in the form of power points, videos, and posters. The implementation stage is in the form of a pre-test, material presentation, discussion/question-answer session, post-test, and awarding of the best participants. All activities are carried out online through the Zoom Meeting application. Target participants include educational institutions, government, high school/vocational high school students, the general public, and health practitioners. The evaluation stage was carried out by analyzing all data descriptively regarding the number of participants, the origin of participants, and pre-test and post-test scores. The results of this activity included the number of participants who took part in PKM as many as 60 with 96% of participants coming from West Java (Bekasi). The average value of pre-test to post-test increased from 62 to 83 or increased by 55%. This PKM concludes that the community can understand educational materials as evidenced by the accuracy of answering questions such as the function, impact, source, and dose of vitamin A, zinc, iodine, and iron to prevent stunting potential.
Tingginya kandungan protein pada kedelai berbanding lurus dengan kadar senyawa flavonoid. Formulasi pembuatan tablet dari bubuk kedelai hitam Detam II sulit ditentukan karena kandungannya yang membuat sulit untuk mendapatkan kekerasan tablet yang optimal. Penelitian ini bertujuan untuk mendapatkan formulasi tablet kedelai hitam varietas detam II. Penelitian dilaksanakan pada bulan Februari sampai Oktober 2020 di Laboratorium Teknologi Farmasi STIKes Mitra Keluarga. Pembuatan tablet kedelai hitam (Glycine max L.) varietas detam II dengan metode slugging. Tablet kedelai hitam Detam II (Glycine max L.) dibuat menjadi 5 formula dengan kandungan 250 mg bubuk kedelai hitam (Glycine max L.) varietas detam II pada setiap formula. Variabel yang membedakan adalah senyawa eksipien tablet pada masing-masing formula yaitu PVP K30, gelatin, dan amilum maydis sebagai bahan pengisi-pengikat. Kami menggunakan tipe eksperimen trial and error untuk membuat setiap formula. Evaluasi granul tablet kedelai hitam (Glycine max L.) varietas detam II dengan pengujian kadar air, kompresibilitas, waktu alir, sudut istirahat dan evaluasi tablet dengan pengujian organoleptik, berat, kekerasan, kerapuhan dan waktu hancur. Hasil penelitian menunjukkan bahwa formula 3, 4 dan 5 merupakan formulasi yang direkomendasikan untuk pembuatan tablet kedelai hitam (Glycine max L.) varietas detam II meskipun semua formula ( F1-F5) berada di bawah persyaratan nilai kerapuhan karena beberapa faktor. . Eksipien gelatin dan PVP K30 untuk pembuatan tablet kedelai hitam (Glycine max L.) varietas detam II merupakan pilihan terbaik sebagai pengisi-pengikat tablet.
<p>One of the natural ingredients that is often developed as an antibacterial product is the date palm (<em>Phoenix dactylifera</em>). However, scientific evidence regarding the effectiveness of the antibacterial compounds contained in dates needs to be evaluated, considering that several previous studies have reported that dates are more dominant as antioxidants than as antibacterials. Therefore, it is necessary to reevaluate the antibacterial ability of the methanolic extract of the sukkari variety date palm against the three test bacteria that cause acne, namely <em>P. acnes</em>, <em>S. epidermidis</em> and <em>S. aureus</em>. This research aimed to determine the sensitivity of the three bacteria tested in response to the methanol extract of the sukkari dates. This research design is experimental. The samples tested were sukkari and the tested bacteria were <em>P. acnes, S. epidermidis </em>and<em> S. aureus</em>. Dates were extracted by maceration method and made in concentrations of 50%, 60%, 70%, 80% and 90%. Positive control was chloramphenicol antibiotic while negative control was sterile distilled water. All treatments including control (+) and (-) were given to the test bacteria using the Kirby Baeur method to see the diameter of the zone of inhibition of the test bacteria growth. The data was processed in tabular form and compared with the 2016 CLSI standard to see the sensitivity response of the test bacteria. Results of this research is<strong> </strong>the sukkari dates extract with concentrations of 50%, 60%, 70%, 80% and 90% was able to inhibit the growth of <em>P. acnes, S. epidermidis</em> and <em>S. aureus</em> bacteria with an interval of 7.0-10.0 mm in diameter of the zone of inhibition. All the tested bacteria showed a sensitivity response in the resistant category, so the sukkari dates fruit extract is not the main choice to be developed as a natural anti-acne product.</p>
One of the most dominant types of preparations used by the public is tablets. This community service and empowerment (CSE) aims to introduce and provide training on making tablets with innovative tablet printing machine technology in the pharmaceutical industry and to build partners with SMKs to provide access to education for the vocational level by science and technology while at the same time offering a scholarship program as access to continuing higher education at STIKes Mitra Keluarga for high achieving and financially disadvantaged students. This CSE method includes planning carried out by making an offer to the Pharmacy Vocational School in Bekasi City and making activity flyers to be distributed for class 12, 10, and 11. The implementation was carried out by giving pre-tests, materials, and simulation practices for making drugs with tablet printing machines at STIKES Mitra Keluarga. The evaluation stage is carried out by giving post-test questions. Data analysis in this study was carried out using descriptive and comparative tests using paired t-tests. The results of this CSE show that the value of knowledge and understanding of 35 students before being given material treatment and training was 57 and after being given treatment it was 94 with a percentage increase of 43%. Therefore, this CSE activities is able to increase the knowledge and understanding of 35 class X, XI and XII students of the Bakti Kartini Pharmacy Vocational School regarding making medicine using a tablet printing machine in a real way.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.