Formulasi dan Karakterisasi SNEDDS Ekstrak Jinten Hitam (Nigella Sativa) dengan Fase Minyak Ikan Hiu Cucut Botol (Centrophorus Sp) serta Uji Aktivitas Imunostimulan

Beandrade, Maya Uzia

doi:10.20961/jpscr.v3i1.15506

Cited by 13 publications

(10 citation statements)

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“…The small size of SNEDDS particles could minimize Brown movement between nanoemulsion particles that could prevent segregation, deposition, creaming, and cracking. The hot and cold test and freeze-thawing suggest that SNEDDS SBGE could survive temperature changes (Beandrade, 2018) . Several factors in uence the stability of a drug product, namely, active ingredient stability, the interac-tion between active ingredients and excipient, manufacturing process, type of preparation, container/closing system for packing, light condition, heat, humidity during delivery, storage, and handling (Zothanpuii et al, 2020) .…”

Section: Snedds Analysis With Psamentioning

confidence: 98%

Novel Self-Nanoemulsifying Drug Delivery System of Single Bulb Garlic: Stability, Toxicity, and Antiinflammation in 3T3-L1 Cells

Miasih

Annisa

Lestari

et al. 2022

Sci. Technol. Indones

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Single bulb garlic (SBG) has the potential as an immunomodulator; however, it has low solubility and bioavailability. A lipid-based delivery system, that is, the self-nanoemulsifying drug delivery system (SNEDDS), offers a novel opportunity in drug delivery. SBG can be a suitable candidate for SNEDDS development. This research aims to describe the physical stability, toxicity test of the SNEDDS, and SNEDDS SBG potential as antiinflammation in 3T3-L1 cells. The SNEDDS is made with various ratios of concentrations of carrier oil, surfactants, and cosurfactants, namely, 0.50: 3.45: 0.96, and added with SBG extract (SBGE) of 20 mg/mL. The results of the response test of SNEDDS SBGE formulation indicate an average and standard deviation of emulsification time of 16.38±3.01 (second), pH 7.21±0.08, and transmittance of 98.40±0.23(%). The average nanoemulsion size is 14.333±0.416 nm, polydispersion index of 0.213±0.056, and zeta potential of -14.67±0.72 mV. The results of the physical stability test indicate no segregation, deposition, cracking, or creaming in all nanoemulsion samples and SNEDDS SBG. The MTT test in a dose of 62.5, 125, 250, 500, 100, 2000, and 4000 µg/mL suggests that the highest viability of the 3T3-L1 cells is at a dose of 2000 µg/mL, which is 97.83%±1.55%. Therefore, SNEDDS SBGE can be a potential candidate for oral preparation by increasing bioavailability and reducing toxicity in the 3T3-L1 cells. An antiinflammatory test on the TNF-𝛼 and IL-1𝛽 expressions influences the 3T3-L1 cells. the SNEDDS of SBGE has the potential to reduce the expression of TNF-𝛼 and IL-1𝛽 and increase IL-10 expression in the methylglyoxal-induced 3T3-L1 cells.

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Section: Snedds Analysis With Psamentioning

confidence: 98%

Novel Self-Nanoemulsifying Drug Delivery System of Single Bulb Garlic: Stability, Toxicity, and Antiinflammation in 3T3-L1 Cells

Miasih

Annisa

Lestari

et al. 2022

Sci. Technol. Indones

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“…Minyak merupakan komponen penentu dalam pembentukan nanoemulsi karena sebagai pembawa zat aktif sehingga jenis yang dipilih berdasarkan pada kelarutan zat aktif (Singh et al, 2017). Minyak tulang ikan sidat dapat diformulasi menjadi nanoemulsi yang baik karena tersusun dari asam lemak rantai hidrokarbon menengah dan panjang (Beandrade, 2018;Aprilya et al, 2021). Penelitian sebelumnya telah dilakukan diantaranya adalah karakterisasi nanoemulsi dengan pembawa minyak ikan dan zat aktif dari bahan alam (Zhong et al, 2018;Djamil et al, 2020) dan uji antihiperlipidemia pada minyak ikan sidat (Kontostathi et al, 2021).…”

Section: Alchemy Jurnal Penelitian Kimiaunclassified

Karakterisasi Nanoemulsi Minyak Tulang Ikan Sidat dengan Ekstrak Daun Salam dan Uji Aktivitas Antihiperlipidemia

Prihapsara

Artanti²,

Hanun³

et al. 2023

ALCHEMY J.Pen.Kim

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Pemanfaatan limbah terbuang dari pengolahan ikan sidat (Anguilla spp.) dapat diekstraksi menjadi minyak yang kaya manfaat. Kandungan asam lemak tak jenuh yang tinggi dalam minyak ikan sidat bermanfaat untuk kesehatan salah satunya sebagai antihiperlipidemia. Kombinasi dengan ekstrak bahan alam yaitu ekstrak daun salam (Syzygium polyanthum (Wight) Walp) diharapkan memiliki efek sinergis sebagai agen antihiperlipidemia. Formulasi kombinasi kedua bahan tersebut dibuat dalam sistem penghantaran obat berbasis lipid-based drug delivery system (LBDDS) yaitu dalam bentuk nanoemulsi dengan tujuan untuk meningkatkan kelarutan dan bioavailabilitas. Penelitian ini bertujuan untuk menganalisis kandungan minyak tulang ikan sidat, karakteristik formula nanoemulsi minyak tulang ikan sidat-ekstrak daun salam (NME) dan aktivitas antihiperlipidemia formula NME. Minyak tulang ikan sidat mengandung komposisi SAFA (Saturated Fatty Acid) 40,02%, MUFA (Mono Unsaturated Fatty Acid) 45,58% dan PUFA (Poly Unsaturated Fatty Acid) 14,40% yang termasuk asam lemak rantai sedang hingga rantai panjang. Formula NME memenuhi kriteria ukuran partikel nanoemulsi yaitu sebesar 36,45 nm dengan nilai indeks polidispersitas (PI) sebesar 0,199 serta potensial zeta -21,20 mV. Kombinasi NME-Simvastatin paling efektif menurunkan kadar kolesterol total pada mencit (Mus musculus).Nanoemulsion Characterization of Eel Bone Oil with Bay Leaf Extracts and Antihyperlipidemic Activity Test. The utilization of waste from processing eel (Anguilla spp.) can be extracted into beneficial oil. The high content of unsaturated fatty acids in eel fish oil is beneficial for health, such as anti-hyperlipidemia. In combination with extracts of natural ingredients, bay leaf extract (Syzygium polyanthum (Wight) Walp) is expected to have a synergistic effect as an antihyperlipidemic agent. The combination formula of the two ingredients was made in a lipid-based drug delivery system (LBDDS) in the form of a nanoemulsion to increase solubility and bioavailability. This study aimed to analyze the content of eel bone oil, the characteristics of the nanoemulsion formula of bay leaf extract-eel bone oil (NME), and the antihyperlipidemic activity of the NME formula. Eel bone oil contains a composition of SAFA (Saturated Fatty Acid) of 40.02%, MUFA (Mono Unsaturated Fatty Acid) of 45.58%, and PUFA (Poly Unsaturated Fatty Acid) of 14.40%, which includes medium-to long-chain fatty acids. The NME formula has a particle size of 36.45 nm, a polydispersity index (PI) of 0.199, and a zeta potential of -21,2 mV. The combination of NME–Simvastatin is the most effective in influencing changes in lipid profiles.

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“…Hasil yang diperoleh menunjukkan bahwa nanoemulsi yang dihasilkan memiliki ukuran droplet sesuai dengan karakteristik nanoemulsi yakni dalam rentang 20-500 nm dan indeks polidispersitas (PI) mendekati nol. Rendahnya nilai indeks polidispersitas yang dihasilkan (semakin mendekati nol) tersebut menunjukkan keseragaman ukuran globul pada sediaan semakin tinggi (Beandrade, 2018;Olii et al, 2014). Sementara itu, evaluasi tipe emulsi dilakukan menggunakan metode pengenceran, yaitu menambahkan sejumlah air dan sejumlah minyak pada sampel, dan diamati apakah sediaan dapat tercampur dengan air atau dengan minyak.…”

Section: Karakterisasi Nanoemulsiunclassified

FORMULATION AND PHYSICAL STABILITY TEST OF NANOEMULGEL CONTAINING Petrosia Sp. ETHANOLIC EXTRACT

Malaka

Indalifiany

Sahidin

et al. 2022

JFSP

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Petrosia sp. is one of the sponges from the demospongia class that has biological activity as anti-inflammatory, antimalarial, cytotoxic agent, and can be used in nanoemulgel formulation. Nanoemulsion system is thermodynamically stable and produces globule size that can increase the permeability and diffusibility of Petrosia sp. The presence of gelling agent in the nanoemulgel gives the viscosity and spreadability of Petrosia sp nanoemulsion optimally to increase the effectiveness of the active substances on the skin. This study aims to determine the formulation, characterization, and physical stability of nanoemulgel ethanol extract of sponge Petrosia sp. with carbopol 940 as the gel base. Nanoemulsion characterization included transmittance value, particle size, polydispersity index, and type of emulsion formed. The physical stability test of nanoemulgel included centrifugation and freeze thaw tests with organoleptic, pH, viscosity, and dispersibility evaluation. Nanoemulsion of Petrosia sp ethanolic extract with a composition of 1% VCO, 7% Tween-80, and 2% PEG-400 produced an oil-in-water (O/W) nanoemulsion, transmittance value of 94.84%, droplet size of 23.9 nm and particle size distribution of 0.176. The optimum formula for nanoemulgel is F1 with a nanoemulsion concentration of 75 mL and 25 g of gel base produced a clear and transparent nanoemulgel, semi-solid, soft texture, distinctive aroma, pH value of 5, viscosity of 28,000, dispersibility of 5.7 cm and the shape/color did not change after freeze thaw stability test. Based on the data above, it can be concluded that the F1 nanoemulgel formula with carbopol 940 as the base gel produced an optimal nanoemulgel.

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Formulasi dan Karakterisasi SNEDDS Ekstrak Jinten Hitam (Nigella Sativa) dengan Fase Minyak Ikan Hiu Cucut Botol (Centrophorus Sp) serta Uji Aktivitas Imunostimulan

Cited by 13 publications

References 0 publications

Novel Self-Nanoemulsifying Drug Delivery System of Single Bulb Garlic: Stability, Toxicity, and Antiinflammation in 3T3-L1 Cells

Novel Self-Nanoemulsifying Drug Delivery System of Single Bulb Garlic: Stability, Toxicity, and Antiinflammation in 3T3-L1 Cells

Karakterisasi Nanoemulsi Minyak Tulang Ikan Sidat dengan Ekstrak Daun Salam dan Uji Aktivitas Antihiperlipidemia

FORMULATION AND PHYSICAL STABILITY TEST OF NANOEMULGEL CONTAINING Petrosia Sp. ETHANOLIC EXTRACT

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