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An assessment of some heavy metals concentrations in lettuce in irrigated with waste water in Tamale Metropolis in Ghana has been carried out. Analysis of water and lettuce samples revealed that the mean concentrations of Fe, Mn, Cu, Zn, Cd and Pb in lettuce were 0.436, 0.345, 0.068, 0.017, 0.04 and 0.038 mg/L and 0.167, 0.163, 0.104, 0.127, 0.142 respectively. With exception of Mn and Cd, the concentrations of heavy metals in the irrigation water, irrigated soils and irrigated lettuce, were within the FAO recommended levels. The mean concentrations of nutrients (NO 3 -N, SO 4 and PO 4 -P) in the wastewater-irrigated lettuce, and well water-irrigated lettuce were 15.36, 0.88, 0.28 and 19.09, 1.117, 0.0573 respectively. Though, heavy metals concentrations in the lettuce were low, regular monitoring are required to prevent heavy metal accumulation with their attendant health implications in the consuming public.

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