The discovery of the antiretroviral therapy (ART) increased life expectancy of people living with HIV (PLHIV). This chronic condition was associated with other diseases with a higher risk of multiple drug use and drug interactions. Drug interactions can cause therapy failures and side effects. This cross-sectional study was carried out in three specialized clinics located in the northwestern of the state of São Paulo from September to December 2019, and evaluated the potential drug interactions in PLHIV and its impact on virological failure. PLHIV aged 50 years or older were included, using ART and other drugs for more than one year and viral load tests in the last 6 months. The data were obtained through a structured questionnaire and medical records. The interactions were analyzed by the Liverpool drug interaction database. The virological failure was defined as two exams of viral loads above 200 copies/ml. We performed a descriptive analysis of the results. Among the 113 people included in the study, 43.36% acquired the virus after
Introdução: A pneumonia associada à ventilação mecânica (PAV) é uma infecção associada à assistência à saúde com importante morbimortalidade nas unidades de terapia intensiva (UTI). A maioria dos tratamentos antimicrobianos é intravenosa (IV), porém, atualmente devido à resistência bacteriana a esses antibióticos IV, a via inalatória passou a ser utilizada e pesquisada em pacientes com PAV. Objetivo: Revisão de literatura sobre o uso de antibióticos por via inalatória no tratamento da PAV. Método: Revisão bibliográfica acerca de antibióticos de uso inalatário no tratamento da PAV, com dados coletados de dezembro de 2017 a janeiro de 2018, em produçõs publicadas de 2013 a 2018 em bases de dados on-line relacionados à área da saúde - PubMed e Medline. Resultados/Discussão: Antibióticos nebulizados estão indicados em algumas doenças respiratórias, mas na PAV ainda apresentam baixo nível de evidência. As concentrações desses antimicrobianos nos pulmões são superiores àquelas atingidas pela intravenosa e sua menor concentração no sangue reduz efeitos colaterais sistêmicos. Algumas diretrizes atuais indicam o uso em tratamentos de PAV por bactérias multirresistentes à terapia IV, outras aguardam novos estudos com melhora nos níveis de evidência pelos riscos de efeitos colaterais como broncoespasmo e obstrução do fluxo expiratório por drogas nebulizadas. Conclusão: Antimicrobianos nebulizados podem ser promissores no tratamento de PAV, incluindo infecções por bactérias multirresistentes pela alta concentração dessas drogas nos pulmões. Apesar da ampla utilização de antimicrobianos ser comum nas UTIs, estudos ainda apontam baixo nível de evidência em relação a esta terapia. Todos os estudos desta revisão apontam para necessidade de novas pesquisas sobre essas drogas no tratamento da PAV.
Diabetes Mellitus (DM) belongs to the class of metabolic diseases whose main symptom associated with this disease is high blood sugar levels for a long period. It can be considered as a d the main diseases in the world, since it causes a large population, The objective of the present study was to analyze the relationship between the blood glucose values established by the Brazilian Society of Diabetes Mellitus with age and sex in a population of a city in the Northwest of São Paulo. This is a retrospective, qualitativequantitative study, with data collected through an epidemiological survey with a group of people, chosen at random, in a city in the northwest region of São Paulo. Data were obtained through capillary blood glucose, for this purpose the test strip was inserted into the blood glucose device, after perforating the patient's finger with the device needle, once the sample was obtained, the test strip was placed in contact with the drop of blood until filling its deposit and after a few seconds the right-handed monitor showed the blood glucose value. The data obtained were tabulated, analyzed and represented in tables and figures. It was found that 52.38% of the individuals were male, and 47.62% were female. The correlation test between blood glucose and age showed no significant correlation between these variables. Therefore, the detection of Diabetes Mellitus carriers in campaigns is of paramount importance, for the understanding of disorders and diabetes care by the affected individual, their families and health professionals, it is of paramount importance since they have direct contact with the disease.
COVID-19 is an acute viral infection caused by SARS-CoV-2 coronavirus. This pandemic disease stands out for the marked variation in the clinical characteristics of patients, ranging from asymptomatic cases to severe organ dysfunction and death. Serious complications occur in the late phase of the disease or even after viral infection, and thrombotic events are one of these complications. In this context, this study aimed to report a case of an obese, young adult female patient with a complication of pulmonary thromboembolism after infection by COVID-19.
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