Evaluation of drug interactions and their impact on virological failure of people living with HIV/AIDS over 50 years of age / Avaliação das interações medicamentosas e seu impacto no fracasso virológico de pessoas vivendo com HIV/AIDS acima de 50 anos de idade

Abstract

The discovery of the antiretroviral therapy (ART) increased life expectancy of people living with HIV (PLHIV). This chronic condition was associated with other diseases with a higher risk of multiple drug use and drug interactions. Drug interactions can cause therapy failures and side effects. This cross-sectional study was carried out in three specialized clinics located in the northwestern of the state of São Paulo from September to December 2019, and evaluated the potential drug interactions in PLHIV and its impact on virological failure. PLHIV aged 50 years or older were included, using ART and other drugs for more than one year and viral load tests in the last 6 months. The data were obtained through a structured questionnaire and medical records. The interactions were analyzed by the Liverpool drug interaction database. The virological failure was defined as two exams of viral loads above 200 copies/ml. We performed a descriptive analysis of the results. Among the 113 people included in the study, 43.36% acquired the virus after

Nonagenarians in Hyperpolypharmacy: relationship between the level of drug interactions and sociodemographic, clinical, and functional characteristics

“…Among the twenty-nine participants identified in hyperpolypharmacy for this study, sociodemographic, clinical, life habits, functional ability characteristics and drug interaction data were analysed. The prevalence of major and moderate interactions was higher than those observed by Leite et al [8] in a Primary Care Service but lower than in HIV patients [9]. The results revealed that certain characteristics were associated with minor, moderate, and/or major drug interactions more frequently than other characteristics.…”