Erectile dysfunction (ED) can be caused by different diseases and controlled by several genetic networks. In this study, to identify the genes related to ED, the expression profiles of normal and ED samples were investigated by the Gene Expression Omnibus (GEO) database. Seventeen genes were identified as associated genes with ED. The protein and nucleic acid sequences of selected genes were retrieved from the UCSC database. Selected genes were diverse according to their physicochemical properties and functions. Category function revealed that selected genes are involved in pathways related to humans some diseases. Furthermore, based on protein interactions, genes associated with the insulin pathway had the greatest interaction with the studied genes. To identify the common cis-regulatory elements, the promoter site of the selected genes was retrieved from the UCSC database. The Gapped Local Alignment of Motifs tool was used for finding common conserved motifs into the promoter site of selected genes. Besides, INSR protein as an insulin receptor precursor showed a high potential site for posttranslation modifications, including phosphorylation and N-glycosylation. Also, in this study, two Guanine-Cytosine (GC)-rich regions were identified as conserved motifs in the upstream of studied genes which can be involved in regulating the expression of genes associated with ED. Also, the conserved binding site of miR-29-3p that is involved in various cancers was observed in the 3′ untranslated region of genes associated with ED. Our study introduced new genes associated with ED, which can be good candidates for further analyzing related to human ED.

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Diabetes can cause some diseases or abnormalities. One of the disorders caused by diabetes may be erectile dysfunction (ED). ED is sexual dysfunction characterized by the inability to establish or maintain an erect penis during sexual activity and is a complication of men with chronic type 2 diabetes. These processes, disorders and diseases are highly influenced by the genetics of individuals. In this study, the relationship between genes and diabetes and ED has been explored by a system biology approach. For this purpose, the samples from ten control and diabetic-ED rats were collected. After a search in Gene Expression Omnibus (GEO), series with accession number GSE2457 comprising of 5 normal and 5 diabetic-ED rats were selected. Raw CEL files of these samples were normalized with robust multi-array average (RMA) expression measure method by using the linear models for microarray data (LIMMA) R package. The extracted probe IDs were transformed into 10451 unique and validated official gene symbols. Then, differentially expressed genes (DEGs) were identified between control and normal mucosa by employing the LIMMA R package. DEGs were classified by utilizing KEGG to underlying pathways by Enrichr. The expression values of DEGs were used to construct a gene regulatory network (GRN), by the GENEI3 R package. To analyze the topology of constructed GRNs, betweenness centrality was calculated. Genes with higher betweenness centrality scores were then identified, through the CytoNCA. We then took the commonality of DEGs genes and high-top ranking genes from CytoNCA via a predicted interaction network using GeneMANIA as the most likely important genes in erectile dysfunction. Among the 374 DEGs studied, 146 DEGs showed up-regulation and 228 DEGs displayed down-regulation expression in diabetic-ED rats. According to the Volcano plot, the dpp4, LOC102553868, Ndufa412, Oxct1, Atp2b3 and Zfp91 gene down-regulated and Lpl, Retsat, B4galt1 and Pdk4 genes up-regulated in ED and diabetic rats. Furthermore, genes like dpp4 acted as hubs in the inferred GRN.

The most important human senses are vision and hearing, and learning, educational, communication, and emotional activities are widely associated with these two senses so the purpose of this study was to determine the relationship between emotional intelligence and mental health. The research method was descriptive-correlational and the study population consisted of all students with visual and hearing impairment aged 12 years and above in Kermanshah Exceptional Centers and Public Schools. They were studied (28 blind and 58 deaf). The instrument used in this study was Shot emotional intelligence questionnaire, mental health and social anxiety. Pearson correlation coefficient was used to investigate the relationship between emotional intelligence and mental health with social anxiety. The results of stepwise regression coefficient showed that the strongest predictors were emotional intelligence, emotional appraisal and emotional productivity, and mental health, anxiety, and insomnia components in social function which predict the variance of social anxiety as 44%. Pearson correlation coefficients showed that the components of physical symptoms, anxiety and insomnia, social dysfunction and depression were positively correlated with social anxiety. However, the relationship between evaluation and expression of emotion, emotion regulation

Background Undesirable effects Negative feelings among women with unintended pregnancies may have undesirable effects on pregnancy. However, little is known about the effect of positive feelings and protective factors on prenatal mental health of pregnant women. The aim of the present study was to determine the effect of positive psychology-based interventions (PPI) on the happiness of women with unintended pregnancies. Methods This randomized controlled trial that included 40 women with unintended pregnancies was conducted between March and July 2017. The subjects were randomly assigned to receive 10 weekly training sessions based on positive psychology (PPI) (N = 20) or routine prenatal care (N = 20). All subjects received usual prenatal care. The level of happiness and its five domains were measured in three time points: at baseline, immediately after completing the intervention, and 45 days after the end of the intervention. The happiness was assessed using the Oxford Happiness Inventory (OHI). Results In the intervention group, the mean total OHI score increased from 31.3 (at baseline) to 42.5 (after completing ten sessions of PPI), and the increase remained statistically significant at a 45-day follow-up (39.8); P = 0.001. However, the total OHI score did not change significantly during the follow-up (P = 0.339). Satisfaction with life, self-esteem, and subjective well-being improved significantly after the interventions, whereas the increases observed in the scores of positive mood and self-efficacy dimensions were not significant. Conclusion PPIs can improve happiness and its dimensions among women with unintended pregnancies. It is suggested that healthcare planners help women with unplanned pregnancies adapt by formulating strategies to hold training courses with a positive psychology approach and recognize and promote their positive aspects and strengths.

The Islamic Republic of Iran has experienced a sustained fertility decline over the past three decades, with total fertility rates decreasing to below replacement levels. Despite well-documented literature on the relationship between fertility and women's education, no empirical research has compared these trends during the past forty years. The aim of this study was to investigate the relationship between fertility and women's education, in the west of Iran. In an historical longitudinal household survey in 2009, 3443 women who had ever-married were interviewed. This study focused on women's fertility over their lifetime, according to education attainment levels for the period 1954-1993. An inverse relationship was found between age of marriage and the number ofchildren born by 40 years-of-age (P<0.01). Over the last few decades, the number of children born has decreased in all levels of mother's education, furthermore, the highest level of fertility decline was observed among women with an elementary level of education. The results of the study showed declining fertility convergence among the various education levels. Managers and policy makers in addition to encouraging employed women to have more children should also explore the issues for uneducated women and housewives.

Erectile dysfunction (ED) is one of the most common sexual disorders in men. During the past 30 years, there has been no new drug development for ED. Thus, exploring the genetic basis of ED deserves further study, in hope of developing new pharmacological treatments for ED. In this study, Real-Time PCR analysis was used to assess the expression of androgen regulatory protein (Andpro) and pyruvate dehydrogenase kinase 4 (Pdk4) genes in ED. For this purpose, the experiment was performed on 20 men with severe ED and 20 potent men. IIEF-15 was used to determine the ED severity. The study was conducted in the Department of Sexual Medicine of the Kermanshah University of Medical Sciences, Kermanshah, Iran. The EDTA-Na vacuum blood tube was taken from ED patients and controls. Informed consent was obtained from all participants. After blood sampling, RNA was extracted from whole blood. Then cDNA was synthesized. The gene expression was analyzed through the qPCR method. The ß-actin was used as a reference gene. To further study these two proteins, their three-dimensional structures were predicted through I-TASSER. Compared with controls, in ED patients, the expression of the Andpro gene decreased, while the expression of the Pdk4 gene increased (p<0.01). Predicting the structure of the protein showed that Pyruvate Dehydrogenase Kinase 4 had a double subunit and androgen-regulated protein had a single subunit.

Introduction: Premenstrual syndrome has several physical and psychological complications. Since healthy family relationships and normal marital interactions are affected by a woman's physical and mental health, any disorder in this area decreases marital satisfaction and consequently endangers the mental health and survival of the family. Objective: This study aimed to determine the effect of Fordyce happiness training on marital satisfaction and mental health in women with premenstrual syndrome. Materials and Methods: This randomized controlled trial was performed in 2018-2019. A total of 40 women with the premenstrual syndrome were selected by convenience sampling and randomly divided into experimental (n=20) and control (n=20) groups. The experimental group received six sessions of the Fordyce happiness training program at weekly intervals in groups of 10. In both groups, the level of marital satisfaction and mental health was measured by Enriching and Nurturing Relationship Issues‚ Communication‚ and Happiness (ENRICH) marital satisfaction questionnaire, and the Goldberg Mental Health questionnaire three times: before, immediately after, and 45 days after the training sessions. The Chi-square test, Fisher exact test, independent t test, and repeated measures analysis of variance were conducted to analyze the obtained data. Results: The Mean±SD ages of the experimental and control groups were 32.45±7.33 and 33.10±6.25 years, respectively. The mean scores of mental health in the experimental group compared to the control group in the pretest, post-test, and follow-up (43.95±4.38, 41.20±5.73, 40.25±5.88) had a decreasing trend (P<0.05) but the mean scores of marital satisfactions in the experimental group (81.90±7.18, 86.35±8.16, 86.80±7.96, respectively) increased (P<0.05). However, no significant change was observed in the control group. Time significantly affects the mean changes in mental health (P=0.002) and marital satisfaction (P=0.001) in the samples. The time-group effect also shows a significant change for both variables (partial eta-squared for mental health=0.174 and marital satisfaction=0.165); the changes in the mean mental health and marital satisfaction of the research samples over time are different between the experimental and control groups; there are changes in the mean score of the two variables in three time points. Conclusion: The findings of the present study showed that Fordyce happiness training is effective in improving the level of marital satisfaction and mental health of women with premenstrual syndrome. Therefore, it is suggested that this training program is used to adapt women psychologically to the mood and physical changes of premenstrual syndrome.