Amlodipine (AD) is a calcium channel blocker that is mainly used in the treatment of hypertension and angina. However, latest findings have revealed that its efficacy is not only limited to the treatment of cardiovascular diseases as it has shown to possess antioxidant activity and plays an important role in apoptosis. Therefore, it is also employed in the treatment of cerebrovascular stroke, neurodegenerative diseases, leukemia, breast cancer, and so forth either alone or in combination with other drugs. AD is a photosensitive drug and requires protection from light. A number of workers have tried to formulate various conventional and nonconventional dosage forms of AD. This review highlights all the formulations that have been developed to achieve maximum stability with the desired therapeutic action for the delivery of AD such as fast dissolving tablets, floating tablets, layered tablets, single-pill combinations, capsules, oral and transdermal films, suspensions, emulsions, mucoadhesive microspheres, gels, transdermal patches, and liposomal formulations.

The physical mixtures of AA and CT showed no interaction between the two compounds by FTIR spectrometry indicating that the reduction in rates of degradation is due to the antioxidant activity of CT which protected AA to some extent from the atmospheric oxygen.

Riboflavin (RF) is a light sensitive compound and is known to form a number of photoproducts. These photoproducts possess the same nucleus and may interfere in the analysis of RF by UV and visible spectrometry. Therefore, it is necessary to apply the methods of multicomponent spectrometric analysis to quantify the vitamin and its photoproducts accurately. Such methods are useful in the study of the kinetics of photodegradation reactions of RF to obtain accurate and reliable results. Any interference in these methods due to linear or nonlinear irrelevant absorption of the minor unknown products can be accounted for by the application of appropriate correction procedures prior to kinetic treatment. Various factors affecting the accuracy, precision and selectivity of these analytical procedures are also discussed. This review highlights the principles and applications of multicomponent spectrometric methods and their application to the simultaneous determination of RF and its major photoproducts in degraded solutions to evaluate the kinetics of degradation.

Introduction: Among tablets, fast dissolving technology has gained considerable popularity due to their rapid onset of action. Amlodipine besylate (ADB) is a longacting calcium channel blocker that is used in the treatment of angina and hypertension which are life-threatening conditions and require immediate relief. Currently, no fast dissolving tablet dosage form of ADB is commercially available. Methods: A total of seven fast disintegrating tablets of Amlodipine besylate (ADB) have been prepared by direct compression method employing various excipients (Disintegrants and binders) in different concentrations. Pre-compression and post-compression studies were performed along with the storage in the stability chambers under real (30±2ºC / 65±5% RH) and accelerated conditions (40±2ºC / 75±5% RH) for six months. The assay of ADB was performed using a validated UV spectrometric method at 361 nm. Results: The release of ADB from tablets has been found to be very fast with almost more than 85% drug released within 15 min. The release of drug from all the tablet formulations followed Higuchi model. Conclusion: The use of sodium bicarbonate as super disintegrant has greatly promoted the rapid release of the active drug. The binder has been shown to affect the tensile strength of the tablets. The stability studies for six months in aluminum blister packaging indicated no significant change in concentration in the majority of the formulations. This study provides basic groundwork related to the formulation of fast disintegrating tablets of ADB.