Factors affecting formulation characteristics and stability of ascorbic acid in water‐in‐oil creams

Abstract

The physical mixtures of AA and CT showed no interaction between the two compounds by FTIR spectrometry indicating that the reduction in rates of degradation is due to the antioxidant activity of CT which protected AA to some extent from the atmospheric oxygen.

Stabilization of vitamin C in emulsions of liquid crystalline structures

“…At 45 ºC, an important decrease in the Vit C content was observed in both formulations, confirming that the increase in temperature is a determinant factor on the degradation process of Vit C [Sheraz et al, 2014]. At the end of the experiment (after 4 months), the Vit C content obtained from the samples F1 and F2 were 28 % and 33 % respectively.…”

“…The major challenge for the utilization of Vit C is to maintain its chemical stability. Vit C is easily oxidized in aqueous media, in alkaline pH (higher stability is obtained at pH ≤ 4) and in the presence of light, oxygen and metal ions [Stamford, 2012, Comunian et al, 2013, Sheraz et al, 2014, Casanova and Santos, 2016. This process is frequently accompanied by a color change of the formulations, which gradually become yellowish.…”

“…Concerning topical preparations, several publications report the development of drug delivery systems for Vit C; but the chemical stability of this molecule still remains a major concern [Rozman and Gasperin, 2007;Sheraz et al, 2014;Duarah et al, 2017;Maione-Silva et al, 2019]. Derivatives of Vit C, such as sodium ascorbyl phosphate, magnesium ascorbyl phosphate, sodium ascorbate and ascorbyl-6-palmitate have been employed in cosmetic and pharmaceutical formulations in order to remedy this problem [Segall and Moyano, 2008;Serrano et al, 2015].…”

Degradation in Pharmaceutical Creams: Ascorbic Acid Demonstrating Phenomenon: A Review

“…To describe the degradation kinetics in AA cream due to light, Ahmad I and companions in 2011 performed study [33] in which first order degradation rate was evaluated by using spectrophotometer with a reproducibility of ± 5%. Dehydroascorbic acid and 2,3-diketogulonic acid were formed as a photolytic degradation product of AA.…”

Ácido ascórbico associado ao ácido cafeico em formulações tópicas: avaliação da ação antioxidante e peroxidação lipídica

“…Ácido Metafosfórico (INCI:Metaphosphoric acid) -Grau De Pureza Analítico (P.A) o Ácido Sulfúrico (INCI: Sulfuric acid) -Synth ® Pote de vidro cor âmbar, capacidade nominal de 45gBABY et al, 2007;SHERAZ et al, 2014).Posteriormente, o conteúdo foi transferido para potes de vidro herméticos, com capacidade nominal de 45,0 g para cada tipo de preparação protegida da luz. As funções cosméticas dos componentes ativos e a composição qualitativa e quantitativa (% p/p) estão descritas respectivamente no Quadro 2.INCI International Nomenclature of Cosmetic Ingredient (BATISTUZZO et al, 2011).…”