No abstract

Background: The quality of life in patients undergoing hemodialysis is significantly disturbed. There are data that hemodiafiltration (HDF) may be more effective than conventional hemodialysis in the removal of uremic toxins and may reduce frequency and severity of intradialytic and postdialysis adverse symptoms in patients. Also, some researchers suggest advantages of using high-flux membranes compared with low-flux. Objective: The aim of this study was to examine whether hemodialysis modality and membrane flux, independent of membrane biocompatibility, make differences in quality of life in patients. Methods: In our cross-sectional study, we evaluated 124 patients who were divided, based on therapy, into three groups: online HDF, high-flux hemodialysis, and low-flux hemodialysis. Data were collected using the Short Form-36 questionnaire combined with special questionnaire, which included demographic and clinically related questions. Results: Health-related quality of life was better in patients on HDF compared with patients on hemodialysis, especially compared with low-flux hemodialysis patients in most of the scales and in both dimensions: physical component scale and mental component scale. There were no statistically significant differences in Short Form-36 domains between high-flux hemodialysis and low-flux hemodialysis. Conclusion: Our data suggest the potential advantages of HDF with regard to influence on quality of life, which is sufficient to justify further research in prospective and longitudinal study design.

This study indicates that different haemodialysis modalities are associated with insomnia and suggests a potential benefit of using high flux membranes.

Our results show that erythrocyte SOD activity is increased in the early phase of schizophrenia and that depends on age of onset of the disease, the number of psychotic episodes, the duration of the disease and medical treatment.

UVODProces odabira odgovarajućeg fakulteta najčešće je odraz ličnih interesovanja i afiniteta pojedinca. Ako se tome pridoda i proces selekcije koju vrše fakulteti prilikom upisa, na osnovu dotadašnjeg uspeha u školi i znanja pokazanog na prijemnom ispitu, zaključuje se da fakultet upisuju najsposobniji kandidati, sa solidnim predznanjem iz odgovarajućih oblasti, vođeni sopstvenim željama. Na osnovu ovih karakteristika, sa psihološkog aspekta, vreme studiranja se može posmatrati kao period posvećenosti ciljevima, ispunjenosti i lične izgradnje. Nažalost, studiranje može da ima i negativan uticaj na psihičko zdravlje studenata. Postojeći podaci ukazuju na to da depresija i drugi mentalni poremećaji predstavljaju sve veći zdravstveni problem u studentskoj populaciji (1-3).Prema dosadašnjim saznanjima, studenti medicine su posebno opterećeni (4). Studije medicine su napornije i traju duže nego na ostalim fakultetima, a studenti se češće suočavaju sa egzistencijalnim pitanjima kao što su patnja i umiranje. Visoka stopa depresivnosti među studentima medicine je dokumentovana u većem broju studija iz različitih zemalja (5-18).Studenti i mladi lekari koji stažiraju takođe su podložniji pojavi depresije u odnosu na opštu populaciju istog godišta pri čemu se stopa depresivnosti znatno povećava sa vremenom provedenim na stažu (19-23). Ovaj problem ne prestaje ni sa početkom profesionalne karijere tako da se beleži relativno visoka prevalenca depresije i kod lekara (24), neretko komplikovana zloupotrebom droga (6) i povećanim rizikom za suicid (25,26