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Children with CVA showed a high rate of inaudible wheezing that disappeared after β agonist inhalation. Changes in the spectrum curve indices also indicated the bronchial reversibility. These results may suggest the characteristics of CVA in children.

Background and objective: An effort-independent breath sound analysis is expected to be a safe and simple method for clinical assessment of changes in airway function. The effects of bronchoconstriction and bronchodilation on novel breath sound parameters in asthmatic children were investigated. Methods: The study population included 49 children with atopic asthma (male = 33; mean age: 10.2 years). We evaluated breath sound parameters of the highest frequency of the power spectrum (HFp), frequency limiting 50% and 99% of the power spectrum (F 50 and F 99 ) and roll-off from 600 Hz to the HFp (Slope). We also assessed new parameters obtained using the ratios of sound spectrum parameters (spectrum curve indices), such as the ratio of the third and fourth power area to the total power area (P 3 /P T and P 4 /P T ), the ratio of the third and fourth areas to the total area under the curve (A 3 /A T and B 4 /A T ) and the ratio of power and frequency at 75% of HFp and 50% of HFp (RPF 75 and RPF 50 ). This was measured before and after methacholine inhalation challenge and after β 2 agonist inhalation. Results: The parameters, F 50 and F 99 , showed no changes after methacholine inhalation. Conversely, the A 3 /A T (12.5-10.0%, P < 0.001), B 4 /A T (7.6-5.5%, P < 0.001), RPF 75 (6.7-4.0 dBm/Hz, P < 0.001) and RPF 50 (5.8-4.3 dBm/Hz, P < 0.001) were significantly decreased. These values returned to the original level after β 2 agonist inhalation. Conclusion: Spectrum curve indices indicate bronchoconstriction and bronchodilation. These parameters may play a role in the assessment of airway narrowing in asthmatic children.