A clinical method for detecting bronchial reversibility using a breath sound spectrum analysis in infants

Enseki, Mayumi; Nukaga, Mariko; Tabata, Hideyuki; Hirai, Kota; Matsuda, Shinichi; Mochizuki, Hiroyuki

doi:10.1016/j.resinv.2016.11.005

Cited by 20 publications

(24 citation statements)

References 34 publications

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“…However, a lung sound analysis is useful in infants and younger children. 14,18,20 The present findings suggest that this clinical approach provides useful information about bronchial constriction. It may be feasible to develop more suitable respiratory function parameters for use in infants and younger children.…”

Section: Discussionsupporting

confidence: 54%

“…As a pulmonary function test, the accuracy of the spectrum curve indices may be less than that of common spirometric parameters. However, a lung sound analysis is useful in infants and younger children . The present findings suggest that this clinical approach provides useful information about bronchial constriction.…”

Section: Discussionmentioning

confidence: 64%

“…In recent reports, we demonstrated the reliability of our breath sound analysis method and its possible application to the assessment of bronchial constriction in children. 14,32 It is noteworthy that the spectrum curve indices of the simple method, A 3 /A T , B 4 /A T , RPF 50 and RPF 75 , had only a minor impact from airflow rate. 13,14 It is feasible that a breath sound analysis method will enable the diagnosis of young asthmatic children by evaluating the breath sound changes during tidal breathing in a period of just 30 s.…”

Section: Discussionmentioning

confidence: 98%

“…Based on the findings of recent reports, 14,36 removal of noise during lung sound collection is an important priority. Furthermore, the lung sound analysis is an indirect approach to assessing the pulmonary function and how to collect the lung sounds stably in infants and small children remains problematic.…”

Section: Discussionmentioning

confidence: 99%

“…Pulmonary function has a major effect on the airflow during breathing, and age and body size remarkably affect the pulmonary function of children . In consideration of this problem, we have defined new respiratory sound parameters which are mostly unaffected by the airflow rate . The aim of the present study was to study the changes of breath sound parameters caused by bronchoconstriction and bronchodilation using methacholine inhalation challenge, and to evaluate the possibility of breath sound analysis in asthmatic children.…”

Section: Introductionmentioning

confidence: 99%

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Changes in the breath sound spectrum during methacholine inhalation in children with asthma

et al. 2017

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Background and objective: An effort-independent breath sound analysis is expected to be a safe and simple method for clinical assessment of changes in airway function. The effects of bronchoconstriction and bronchodilation on novel breath sound parameters in asthmatic children were investigated. Methods: The study population included 49 children with atopic asthma (male = 33; mean age: 10.2 years). We evaluated breath sound parameters of the highest frequency of the power spectrum (HFp), frequency limiting 50% and 99% of the power spectrum (F 50 and F 99 ) and roll-off from 600 Hz to the HFp (Slope). We also assessed new parameters obtained using the ratios of sound spectrum parameters (spectrum curve indices), such as the ratio of the third and fourth power area to the total power area (P 3 /P T and P 4 /P T ), the ratio of the third and fourth areas to the total area under the curve (A 3 /A T and B 4 /A T ) and the ratio of power and frequency at 75% of HFp and 50% of HFp (RPF 75 and RPF 50 ). This was measured before and after methacholine inhalation challenge and after β 2 agonist inhalation. Results: The parameters, F 50 and F 99 , showed no changes after methacholine inhalation. Conversely, the A 3 /A T (12.5-10.0%, P < 0.001), B 4 /A T (7.6-5.5%, P < 0.001), RPF 75 (6.7-4.0 dBm/Hz, P < 0.001) and RPF 50 (5.8-4.3 dBm/Hz, P < 0.001) were significantly decreased. These values returned to the original level after β 2 agonist inhalation. Conclusion: Spectrum curve indices indicate bronchoconstriction and bronchodilation. These parameters may play a role in the assessment of airway narrowing in asthmatic children.

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Section: Discussionsupporting

confidence: 54%

Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Changes in the breath sound spectrum during methacholine inhalation in children with asthma

et al. 2017

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Lung sound analysis in infants with risk factors for asthma development

Miyamoto

Yoshihara

Shioya

et al. 2021

Health Science Reports

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Background and objectives Using a lung sound analysis, the prognosis of asthma was investigated in infants with risk factors for asthma development by a long‐term observation. Methods A total of 268 infants were included (median age: 8 months old). The lung sound parameters (the ratio of the third and fourth area to the total area under the curve [A 3 /A T and B 4 /A T ], and the ratio of power and frequency at 50% and 75% of the highest frequency [RPF 50 and RPF 75 ]) were evaluated at the first visit. At 3 years old, using a questionnaire, we examined the relationship between the lung sound parameters and risk factors of asthma development. Results Among the 268 infants, 175 infants were in good health and 93 had a history of acute respiratory infection (ARI) within 7 days at the first visit. Among the 3‐ to 12‐month‐old infants with an ARI, the A 3 /A T , B 4 /A T values in those with a history of asthma/asthmatic bronchitis, atopic dermatitis, and atopy were smaller than in the infants without such histories. Among the 13‐ to 24‐month‐old infants with an ARI, the A 3 /A T and B 4 /A T values in those with a wheezing history were larger than in the infants without such a history. Conclusions The characteristics of the lung sounds in infants with risk factors for asthma development were demonstrated over long‐term follow‐up. Lung sound analyses may be useful for assessing the airway condition of infants.

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Breath sound analyses of infants with respiratory syncytial virus acute bronchiolitis

Kuruma

Otomo²,

Sakama³

et al. 2022

Pediatric Pulmonology

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Introduction:The reliability of a breath sound analysis using an objective method in infants has been reported.Objective: Breath sounds of infants with respiratory syncytial virus (RSV) acute bronchiolitis were analyzed via a breath sound spectrogram to evaluate their characteristics and examine their relationship with the severity. Subjects and Methods:We evaluated the inspiratory and expiratory breath sound parameters of 33 infants diagnosed with RSV acute bronchiolitis. The sound powers of inspiration and expiration were evaluated at the acute phase and recovery phase of infection. Furthermore, the relationship between the breath sound parameters and the clinical severity of acute bronchiolitis was examined.Results: Analyses of the breath sound spectrogram showed that the power of expiration as well as the expiration-to-inspiration sound ratio in the mid-frequency (E/I MF) was increased in the acute phase and decreased during the recovery phase.The E/I MF was inversely correlated with the SpO 2 and positively correlated with the severity score. Conclusion:In infants with RSV acute bronchiolitis, the sound power of respiration was large at the acute phase, significantly decreasing in the recovery phase. In 61% of participants, nonuniform, granular bands were shown in the low-pitched region of the expiratory spectrogram.

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A clinical method for detecting bronchial reversibility using a breath sound spectrum analysis in infants

Cited by 20 publications

References 34 publications

Changes in the breath sound spectrum during methacholine inhalation in children with asthma

Changes in the breath sound spectrum during methacholine inhalation in children with asthma

Lung sound analysis in infants with risk factors for asthma development

Breath sound analyses of infants with respiratory syncytial virus acute bronchiolitis

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