Cisplatin, given daily in combination with the radiotherapy described here to patients with nonmetastatic but inoperable non-small-cell lung cancer, improved rates of survival and control of local disease at the price of substantial side effects.

There was no pharmacokinetic-sequence interaction between C and P in this study. A clear dose-response relation with respect to response rate and survival was observed. The pharmacokinetic parameter P-T > or = 0.1 mumol/L was related to improved survival in this study.

Trends in Content-based Recommenders New Metadata Encodings Linked Open Data Usergenerated Content Visual and MulƟmedia Features Meta-Path based Approaches Algorithmic Data Related Deep Learning Heterogeneous InformaƟon Networks

The aim of the present study was to evaluate the implementation of the 2003 Dutch guideline on the diagnosis and treatment of malignant pleural effusions, and the potential effect of the implementation on the clinical outcome of pleurodesis.All patients with malignant pleural effusion who had a pleural drain placed with the intention of performing pleurodesis were registered prospectively in four centres. Details of the procedure and fluid recurrence and survival data were noted.Patients with a proven malignancy (n5100) were entered into the registration database. Diagnostic guideline recommendations were followed in 60-70% of the patients. Surprisingly, pleurodesis was performed in only 75% of the patients, mainly due to the presence of a trapped lung. All pleurodeses were performed using talc, according to the guideline. Follow-up revealed fluid recurrence in 27 (36%) patients after a mean follow-up of 17 days (range 2-285 days); 14 patients with successful pleurodesis died with a median survival of 61 days (range 13-174 days). Systemic treatment following pleurodesis and good apposition of the pleural surfaces during drainage were good prognostic factors.Despite reasonable-to-good adherence to the guideline, the number of successful pleurodeses was low. Better predictors of a good pleurodesis outcome are needed.

In this paper, we investigate the difference between Wikipedia and Web link structure with respect to their value as indicators of the relevance of a page for a given topic of request. Our experimental evidence is from two IR test-collections: the .GOV collection used at the TREC Web tracks and the Wikipedia XML Corpus used at INEX. We first perform a comparative analysis of Wikipedia and .GOV link structure and then investigate the value of link evidence for improving search on Wikipedia and on the .GOV domain. Our main findings are: First, Wikipedia link structure is similar to the Web, but more densely linked. Second, Wikipedia's outlinks behave similar to inlinks and both are good indicators of relevance, whereas on the Web the inlinks are more important. Third, when incorporating link evidence in the retrieval model, for Wikipedia the global link evidence fails and we have to take the local context into account.

No abstract

This paper gives an overview of the INEX 2008 Ad Hoc Track. The main goals of the Ad Hoc Track were twofold. The first goal was to investigate the value of the internal document structure (as provided by the XML markup) for retrieving relevant information. This is a continuation of INEX 2007 and, for this reason, the retrieval results are liberalized to arbitrary passages and measures were chosen to fairly compare systems retrieving elements, ranges of elements, and arbitrary passages. The second goal was to compare focused retrieval to article retrieval more directly than in earlier years. For this reason, standard document retrieval rankings have been derived from all runs, and evaluated with standard measures. In addition, a set of queries targeting Wikipedia have been derived from a proxy log, and the runs are also evaluated against the clicked Wikipedia pages. The INEX 2008 Ad Hoc Track featured three tasks: For the Focused Task a ranked-list of nonoverlapping results (elements or passages) was needed. For the Relevant in Context Task non-overlapping results (elements or passages) were returned grouped by the article from which they came. For the Best in Context Task a single starting point (element start tag or passage start) for each article was needed. We discuss the results for the three tasks, and examine the relative effectiveness of element and passage retrieval. This is examined in the context of content only (CO, or Keyword) search as well as content and structure (CAS, or structured) search. Finally, we look at the ability of focused retrieval techniques to rank articles, using standard document retrieval techniques, both against the judged topics as well as against queries and clicks from a proxy log.

Abstract. Real-world information needs are generally complex, yet almost all research focuses on either relatively simple search based on queries or recommendation based on profiles. It is difficult to gain insight into complex information needs from observational studies with existing systems; potentially complex needs are obscured by the systems' limitations. In this paper we study explicit information requests in social media, focusing on the rich area of social book search. We analyse a large set of annotated book requests from the LibraryThing discussion forums. We investigate 1) the comprehensiveness of book requests on the forums, 2) what relevance aspects are expressed in real-world book search requests, and 3) how different types of search topics are related to types of users, human recommendations, and results returned by retrieval and recommender systems. We find that book search requests combine search and recommendation aspects in intricate ways that require more than only traditional search or (hybrid) recommendation approaches.