Purpose:Our aim was to report the case of endothelial corneal allograft rejection after inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine with an atypical presentation.Methods:This was a case report.Results:A 63-year-old woman with previous penetrating keratoplasty and laser in situ keratomileusis presented with clinical signs of endothelial corneal graft rejection 24 hours after CoronaVac (SinoVac Biotech, Beijing/China) vaccine. Slitlamp examination showed corneal edema and interface fluid accumulation. It was partially resolved after treatment with topical corticosteroids and polydimethylsiloxane.Conclusions:Corneal allograft rejection was already reported after another SARS-CoV-2 vaccine. This is the first report in the literature describing a possible association with inactivated SARS-CoV-2 vaccine and corneal allograft rejection, especially with laser in situ keratomileusis interface fluid accumulation presentation. Ophthalmologists should be aware of this potential complication.

Analysis of a PAT modeling is presented for application in water pipe systems as an interesting and promising energy converter to improve the system energy efficiency. The study is focused on the use of a Computational Fluid Dynamics (CFD) model in conjunction with laboratory data for representing PAT performance. The first stage of the procedure concerns a systematic analysis of the role played by the characteristic PAT parameters in the computational mesh definitions of the CFD model, with the aim of defining the most efficient set of capturing the main features of the PAT behaviour under different operating conditions. In the second stage, comparisons of CFD results and experiments were carried out to examine some system components for better understanding the PAT response. Specifically, the behavior of the pressure distribution along the PAT installation when implemented in a water pipe system are analyzed, and the links between pressure variation and the head drop in different system components responsible for the head losses and net head definition are also examined.

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Sea urchins have hundreds of specialized adhesive organs, the tube feet, which play a key role in locomotion, substrate attachment and food capture. Tube feet are composed by two functional units: a proximal cylindrical stem that is mobile and flexible, attached to a distal flattened disc that produces adhesive secretions. Oral tube feet discs possess a specialized duo-glandular epidermis that produces adhesive and de-adhesive secretions, enabling strong but reversible adhesion to the substrate. Due to the growing interest in biomimetic adhesives, several studies have been carried out to characterize sea urchin adhesives, and up to date, it has been shown that it is composed by proteins and glycans. The protein fraction has been the subject of several studies, that pin-pointed several adhesion-related candidates. Contrastingly, little is known about the glycans that compose sea urchin adhesives. This study aims at contributing to this topic by focusing on the characterization of the glycosidic fraction of the adhesive secreted by the sea urchin Paracentrotus lividus (Lamarck, 1816), using a battery of 22 lectins, applied to 3 complementary techniques. Our results show that five lectins label exclusively the disc adhesive epidermis and simultaneously the secreted adhesive, being, therefore, most likely relevant for sea urchin adhesion. In addition, it was possible to determine that the glycosidic fraction of the adhesive is composed by a high molecular weight glycoprotein containing N-acetylglucosamine oligomers.

This research provides useful insights for better diagnosis and understanding the vein blockage induced by a deep venous thrombosis and the occurrence of reverse flow in human veins, allowing a proper detection of serious diseases related to deep venous insufficiency. An arbitrary Lagrangian-Eulerian formulation is used in a coupled model (i.e. fluid and structure equations solved together), considering two domains, specifically the blood flow and the flexible structures (i.e. vein and valves). Computational fluid dynamics mathematical model based on finite element method, with special elements and boundary characterization, is addressed to find the best solution. This research presents a novel model to study the interaction between non-Newtonian laminar fluid flows, the blood, within nonlinear structures, the vein walls. Simulation results are validated using in vivo echo-Doppler measurements.

Velocity profiles originated by a pump as turbine (PAT) were measured using an ultrasonic doppler velocimetry (UDV). PAT behavior is influenced by the velocity data. The effect of the rotational speed and the associated flow velocity variations were investigated. This research focuses, particularly, on the velocity profiles achieved for different rotational speeds and discharge values along the impeller since that is where the available hydraulic power is transformed into the mechanical power. Comparisons were made between experimental test results and computational fluid dynamics (CFD) simulations. The used CFD model was calibrated and validated using the same conditions as the experimental facility. The numerical simulations showed good approximation with the velocity measurements for different cross-sections along the PAT system. The application of this CFD numerical model and experimental tests contributed to better understanding the system behavior and to reach the best efficiency operating conditions. Improvements in the knowledge about the hydrodynamic flow behavior associated with the velocity triangles contribute to improvements in the PAT concept and operation.

Abstract:Computational fluid dynamics (CFD) can be seen as complementary tool alongside the visualization capabilities of cardiovascular magnetic resonance (CMR) and computed tomography (CT) imaging for decision-making. In this research CT images of three cases (i.e., a healthy heart pilot project and two patients with complex aortic disease) are used to validate and analyse the corresponding computational results. Three 3D domains of the thoracic aorta were tested under hemodynamic conditions. Under normal conditions, the flow inside the thoracic aorta is more streamlined. In the presence of ascending aortic aneurysm, large areas of blue separation zones (i.e., low velocities) are identified, as well as an internal geometry deformation of the aortic wall, respectively. This flow separation is characterized by the reversal of flow and sudden drop of the wall shear stress (WSS) in the aorta. Moreover, the aortic aneurysm simulations adversely affect the flow by increasing the pressure drop and flow inefficiency, due to the anatomical configuration of the ascending aorta. Altered hemodynamics led to a vortex formation and locally reversed the flow that eventually induced a low flow velocity and oscillating WSS in the thoracic aorta. Significant changes in the hemodynamic characteristics affect the normal blood circulation with strong turbulence occurrence, damaging the aortic wall, leading ultimately to the need of surgical intervention to avoid fatal events.

Micro-hydro systems can be used as a promising new source of renewable energy generation, requiring a low investment cost of hydraulic, mechanical, and electrical equipment. The improvement of the water management associated with the use of pumps working as turbines (PATs) is a real advantage when the availability of these machines is considered for a wide range of flow rates and heads. Parallel turbomachines can be used to optimize the flow management of the system. In the present study, experimental tests were performed in two equal PATs working in parallel and in single mode. These results were used to calibrate and validate the numerical simulations. The analysis of pressure variation and head losses was evaluated during steady state conditions using different numerical models (1D and 3D). From the 1D model, the installation curve of the system was able to be defined and used to calculate the operating point of the two PATs running in parallel. As for the computational fluid dynamics (CFD) model, intensive analysis was carried out to predict the PATs′ behavior under different flow conditions and to evaluate the different head losses detected within the impellers. The results show system performance differences between two units running in parallel against a single unit, providing a greater operational flow range. The performance in parallel design conditions show a peak efficiency with less shock losses within the impeller. Furthermore, by combining multiple PATs in parallel arrangement, a site’s efficiency increases, covering a wide range of applications from the minimum to the maximum flow rate. The simulated flow rates were in good agreement with the measured data, presenting an average error of 10%.