Thyroid disorders are common in patients with Down syndrome, which can lead to significant impacts on the quality of life and cognitive development of these patients. Studies report a prevalence of 15-30% of thyroid disorders in patients with Down syndrome. Diagnosis of thyroid disorders in patients with Down syndrome is done using blood tests to measure levels of thyroid hormones and TSH. In addition, clinical evaluation is important to identify possible signs and symptoms of thyroid dysfunction, such as fatigue, weight gain or loss, intolerance to cold or heat, among others. To screen for thyroid disorders in patients with Down syndrome, the American Down Syndrome Society and the European Society recommend regular blood tests from birth and iodine prophylaxis to prevent thyroid dysfunction. The screening protocol must be individualized for each patient, taking into consideration, the factors such as age, family history and exposure to environmental risk factors. Treatment of hypothyroidism in patients with Down syndrome involves replacing thyroid hormones using medications such as levothyroxine. Furthermore, the adoption of non-pharmacological measures, such as diet and physical exercise, can help control the disease. The treatment of hyperthyroidism may involve the use of medications, such as propylthiouracil or methimazole, and, in more severe cases, treatment with radioactive iodine or surgery.
Introduction:Non-opiate analgesics, antipyretics and anti-rheumatics are among the most widely used drugs in the world, as they have symptomatic effects for practically all types of chronic or acute diseases. Objective: To describe the epidemiological profile of hospitalizations due to the accidental use of analgesics, antipyretics and anti-rheumatics. Methodology: This is a descriptive observational study, whose data were collected by the DataSUS platform. The collection started from the Hospital Information System (SIH), through hospital morbidity data by place of residence between January 2007 and December 2021. Results and discussion: The most affected region was the Southeast with 44.5% of all cases in the country, followed by the South, Northeast, Midwest and North regions, respectively. The study can see that the most affected national average age group is represented by two peaks: from one to four years of age and from 20 to 29. The female population represented more than 53% of the hospitalization cases and, when analyzing the color/ race of patients, the white population represented 48.79% of the cases, the brown and black 30% and 3.2%, respectively.
Conclusion:The number of hospitalizations due to accidental use of these medications is still high, mainly because they are routine medications and need to have greater awareness on the part of the population.
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