This study provides a first overview of the burden of GW in Spain. A quadrivalent HPV vaccine that prevents HPV 6, 11, 16, 18 related diseases will have the potential to significantly decrease the socio-economic burden associated with GW in Spain.

Background: A thorough epidemiological surveillance and a good understanding of the burden of diseases associated to VZV are crucial to asses any potential impact of a prevention strategy. A population-based retrospective epidemiological study to estimate the burden of herpes zoster requiring hospitalization in Spain was conducted.

Wind energy requires accurate forecasts for adequate integration into the electric grid system. In addition, global atmospheric models are not able to simulate local winds in complex terrain, where wind farms are sometimes placed. For this reason, the use of mesoscale models is vital for estimating wind speed at wind turbine hub height. In this regard, the Weather Research and Forecasting (WRF) Model allows a user to apply different initial and boundary conditions as well as physical parameterizations. In this research, a sensitivity analysis of several physical schemes and initial and boundary conditions was performed for the Alaiz mountain range in the northern Iberian Peninsula, where several wind farms are located. Model performance was evaluated under various atmospheric stabilities and wind speeds. For validation purposes, a mast with anemometers installed at 40, 78, 90, and 118 m above ground level was used. The results indicate that performance of the Global Forecast System analysis and European Centre for Medium-Range Weather Forecasts interim reanalysis (ERA-Interim) as initial and boundary conditions was similar, although each performed better under certain meteorological conditions. With regard to physical schemes, there is no single combination of parameterizations that performs best during all weather conditions. Nevertheless, some combinations have been identified as inefficient, and therefore their use is discouraged. As a result, the validation of an ensemble prediction system composed of the best 12 deterministic simulations shows the most accurate results, obtaining relative errors in wind speed forecasts that are <15%.

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The relationship between springtime (March-May) precipitation in the western Mediterranean area and several North Atlantic teleconnection patterns of low-frequency variability is analysed for the period 1948-89. Singular value decomposition analysis (SVDA) of the springtime monthly mean fields for the three paired combinations of 300 hPa geopotential height-precipitation, 300 hPa zonal wind-precipitation and 300 hPa meridional wind-precipitation has shown that their covariability is dominated by two main large-scale atmospheric circulation patterns. In every SVD combination, the first mode relates precipitation anomalies to the east Atlantic jet pattern. Above-normal rainfall anomalies are linked with a blocking pattern affecting Iberian weather. The second covariability mode for the three SVD As takes into account the response of the precipitation to the North Atlantic oscillation (NAO) pattern. An enhanced spring NAO pattern is related to positive (negative) precipitation anomalies over the southern (northern) western Mediterranean. Through these two modes, the North Atlantic large-scale atmospheric dynamics explains about 50% of the total spring precipitation variability in the western Mediterranean area. A Monte Carlo approach has allowed setting the statistical significance of the modes obtained and to assess the effectiveness of the western Mediterranean precipitation response to the teleconnection patterns.