Summary
We have treated seven patients with severe rosacea with 1 mg kg−1 day−1 isotretinoin for 12 weeks. There were large reductions in numbers of papules and pustules (P < 0.001) small decreases in measurements of erythema (P < 0.01) and median values for severity were lower during and after treatment. There was evidence of relapse by 8 weeks after stopping isotretinoin. Side‐effects were well tolerated and increases in serum lipids and indices of liver function had reversed by 4 weeks after treatment. We conclude that isotretinoin is effective in rosacea.
We report here the case of a 17-year-old girl from Pelotas, Brazil, with systemic lupus erythematosus and disseminated cryptococcal infection. Prior to diagnosis, she was a chronic user of corticosteroids and other immunosuppressive drugs. Her first symptoms were skin lesions that simulated bacterial cellulitis. Upon suspicion, we performed a biopsy and fungal infection was confirmed. Appropriate therapy was established, and the patient was discharged after 42 days of treatment in complete remission.
Cutaneous involvement in plantar fibromatosis is very rare. The classical finding are nodules in the plantar arch, which can be detected only with palpation. A 55 year-old man presented with a 3 year history of painful plantar nodules and an ulceration. Histopathology showed a fibroblastic proliferation with a pseudosarcomatous configuration. The immunohistochemistry was positive for vimentin, alpha-actin and desmin, a pattern which characterizes a myofibroblast. Intralesional therapy with corticosteroids did not reduce the lesions. After surgical treatment, the lesions recurred.
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