RESUMO: Diante deste artigo, teceremos uma comparação entre as particularidades da Educação a Distância (EAD) e do Ensino Remoto. Visto que muitos indivíduos se apropriam, intitulando o Ensino Remoto como EAD, simplesmente por utilizar a tecnologia em massa no processo de ensino e aprendizagem. Sintetizando, a EAD busca atingir um público maior de alunos, por um ambiente virtual de aprendizagem (AVA), valorizando as atividades assíncronas, protagonizando ainda mais o aluno, no desenvolvimento de sua aprendizagem, Logo, o Ensino Remoto, também utiliza algumas estratégias do EAD, porém é ainda mais rico, pois acrescenta um foco de vinculação entre as atividades síncronas e assíncronas, a fim de alcançar um equilíbrio na aprendizagem mediada por recursos digitais e valorizando a autonomia do educando, inovando em metodologias ativas, inclusive no processo de avaliação.
Graphical Abstract AbstractRetinoblastoma is a pediatric malignant tumor, common in children up to 5 years old. It is a disease commonly developed from retinoblasts [1], therefore the eye presents as the primary symptom the leukocoria (white reflex that occurs when the retina is exposed), this signal occurs due to displacement of the retina caused by tumor growth. The disease can affect only one eye (unilateral) or both eyes (bilateral). Depending on the region in which the tumor develops, the optic nerve and central nervous system may be compromised. Phenylpropanoids are widely studied anti-tumor bioactives in medicinal chemistry, which are present in several studies with good results against brain, breast, prostate and other tumors. This research aims to present, through in silico tools, bioactive with antitumor profile for retinoblastoma of 3,4,5-trihydroxycinnamic acid derivatives.
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