In Silico Studies for Bioactive Proposal Against Human Retinoblastoma From 3,4,5-Trihydroxycinamic Acid Derivatives

Abstract

Graphical Abstract AbstractRetinoblastoma is a pediatric malignant tumor, common in children up to 5 years old. It is a disease commonly developed from retinoblasts [1], therefore the eye presents as the primary symptom the leukocoria (white reflex that occurs when the retina is exposed), this signal occurs due to displacement of the retina caused by tumor growth. The disease can affect only one eye (unilateral) or both eyes (bilateral). Depending on the region in which the tumor develops, the optic nerve and central nervous system may be compromised. Phenylpropanoids are widely studied anti-tumor bioactives in medicinal chemistry, which are present in several studies with good results against brain, breast, prostate and other tumors. This research aims to present, through in silico tools, bioactive with antitumor profile for retinoblastoma of 3,4,5-trihydroxycinnamic acid derivatives.