BackgroundThe nicotine may generate a influence on bone repair and longevity of dental implants. This fact makes studies to improve the surface of the implants are constantly conducted. This study aimed to evaluate the influence of subcutaneous nicotine injection in the osseointegration process on different implant surfaces, through histomorphometric analysis.Material and MethodsTherefore, twenty-two male rabbits were randomly distributed into two groups according to the subcutaneous injections: (1) nicotine, 3 mg/day/kg and (2) 0.9% NaCI, 3 mL/day/kg, three times a day. Subgroups were then designated - machined and anodized dental implants were installed in the right and left tibia bones, respectively. The animals were subjected to euthanasia after periods of eight weeks for histomorphometric analysis. The bone samples with implants were removed and the routine histological processing was performed. Next, the images obtained from the blades were evaluated by the Image Tool™ software, assessing the osseointegrated areas of implants (BIC), in pixels. Data obtained were subjected to intergroup statistical analysis through the Kruskal-Wallis non-parametric test (α=5%).ResultsThe test result showed no statistically significant difference among the groups studied (p=0.446).ConclusionsBased on the methodology studied, it is concluded that the daily application of low doses of nicotine did not interfere with the osseointegration of machined and anodized implants. Key words:Bone-implant interface, implants, osseointegration.
Purpose: To evaluate the influence of subcutaneous injection nicotine in osseointegration process on different implant surfaces. Methods: Twenty-two male rabbits were distributed into two groups according to the subcutaneous injections: (1) nicotine 3 mg/day/kg and (2) 0.9 % NaCI 3 mL/day/kg, three times a day; subgroups were then designated-machined and anodized implants were placed in the right and left tibia bones, respectively. The animals were submitted euthanasia after periods of eight weeks to determine nicotine and cotinine levels, alkaline phosphatase and biomechanical analysis. Results: The plasmatic levels of nicotine and cotinine were 0.5 ± 0.28 ng/mL and 9.5 ± 6.51 ng/mL, respectively. The alkaline phosphatase analyses in blood levels in control group were observed 40.8 ± 11.88 UI/L and 40.75 ± 12.46 UI/L, for the surfaces machined and anodized, respectively. In the test group was observed levels 37.9 ± 4.84 UI/L, for both implant surfaces. No significant differences were observed between control and test groups and between the implant surfaces regarding alkaline phosphatase blood levels. For biomechanics, no significant differences were observed in control group between the machined (25±8.46 Ncm) or anodized (31.2 ± 6.76 Ncm) implants. However, the treatment with nicotine induced higher torque than control in both machined (38.3 ± 13.52 Ncm) and anodized (35.5 ± 14.17 Ncm) implants, with p = 0.0024 and p = 0.0121, respectively. Conclusion: Subcutaneous injection of nicotine following implant insertion didn't have effect on osseointegration, independently from the implant surface.
As superfícies em ambientes de assistência a saúde são facilmente contaminadas. As medidas de desinfecção são essenciais para o controle de infecções. OBJETIVOS: Avaliar e comparar, in vitro, a ação antimicrobiana de desinfetantes de superfície sobre fungos e bactérias, utilizando o método de fricção. MATERIAIS E MÉTODOS: As superfícies de duas mesas foram desinfetadas com álcool 70%, sob fricção, divididas em 64 partes e contaminadas com suspensão microbiana padronizada de fungos e bactérias com turvação correspondente ao número 6 da escala de McFarland. Os desinfetantes testados foram: álcool 70% (A70), ácido peracético 0,2% (AP), dióxido de cloro 7% (DC) e cloreto de benzalcônio 5,2% com polihexametileno biguanida 3,5% (CBPB) que foram friccionados, durante 10 s nas áreas contaminadas. As amostras foram coletadas antes (controle positivo) e após a desinfecção, em triplicata, semeadas em meio de cultura e incubadas por 48 h a 37 ºC. RESULTADOS: O crescimento microbiano foi observado pela presença de unidades formadoras de colônias (UFC) no ágar. Candida albicans foi o microrganismo mais resistente aos produtos selecionados, com exceção do AP, que demonstrou ação contra todos os microrganismos testados. O CBPB foi o único desinfetante que não reduziu a formação de UFC. CONCLUSÃO: O AP obteve o melhor efeito antimicrobiano, sendo a opção mais segura para a desinfecção de alto nível. O A70 e o DC são indicados para a desinfecção intermediária. O CBPB não reduziu a formação das UFC, portanto não é indicado para protocolos de desinfecção.
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