IntroductionBrugada syndrome is a hereditary arrhythmia characterized by a specific electrocardiographic pattern and an increased risk of sudden cardiac death, with an apparent absence of structural abnormalities or ischemic heart disease. To date, mutations in the sodium channel, voltage-gated, type V, alpha subunit gene and glycerol-3-phosphate dehydrogenase 1-like gene are estimated to account for approximately 28% of Brugada syndrome probands.Case presentationWe report the case of a 32-year-old mixed-race Brazilian man who is sodium channel, voltage-gated, type V, alpha subunit gene and glycerol-3-phosphate dehydrogenase 1-like gene mutation-negative with a type 1 Brugada electrocardiographic pattern and a history of high family mortality, including five sudden deaths among relatives of whom four were first-degree relatives.ConclusionTo the best of our knowledge, this is the first case of a patient who has Brugada syndrome and a history of sudden death in four first-degree family members. This case report reinforces the evidence that genetic studies are of limited use while determining risk but remain helpful for diagnosis, and that diagnosis via electrocardiography is of great importance in preventing adverse events and stratifying risk. Although there are several technologically advanced diagnostic tools, they might not be accessible in small towns and hospitals; however, a basic diagnostic tool like electrocardiography is easily accessible.
Objetivo: Identificar as complicações apresentadas por pacientes Pós-Infarto Agudo do Miocárdio (IAM), submetidos a diferentes métodos de revascularização cardíaca como opção terapêutica. Métodos: Trata-se de uma revisão sistemática por meio dos indexadores nas bases de dados eletrônicos Biblioteca Virtual em Saúde (BVS), Medical Literature Analysis and Retrieval System Online (MEDLINE) e Web of Science. Além disso, foi realizado o cálculo do coeficiente de kappa (k) e a escala de Jadad. Resultados: Durante a pesquisa 16 artigos foram selecionados. Observou-se que os principais métodos utilizados foram a Intervenção Coronária Percutânea (IPC) e a Cirurgia de Revascularização Miocárdica (CRVM). No que se refere às complicações verificadas, constatou-se que o IAM foi a complicação mais prevalente, seguido do Acidente Vascular Cerebral (AVC), eventos hemorrágicos, morte pós-operatória e a morte cardíaca. Considerações Finais: Por fim, identificou-se as complicações apresentadas por pacientes Pós-Infarto Agudo do Miocárdio (IAM), submetidos a diferentes métodos de revascularização, se apresentando como fibrilação atrial, morte súbita, disritmias ventriculares, insuficiência cardíaca, processos infecciosos e infarto do miocárdio, além do Acidente Vascular Cerebral (AVC) e eventos hemorrágicos seguidos por morte pós-operatória. Portanto, é imprescindível novas técnicas, alcançando um tratamento adequado.
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