Capsular contracture is a potential adverse effect of breast implants. An inflammatory reaction is most likely the origin of fibrosis around the implant. It is possible that some substances may act to prevent this inflammatory reaction. Thus, our goal was to evaluate the effectiveness of local depot prednisolone phosphate-liposomes (PPL) on fibrous capsule formation around textured silicone breast implants. Shell prostheses (2 mL) were implanted in the right (plus PPL group) and left (plus saline solution, saline group) subcutaneous dorsum of 18 rats. In another 18 rats, the implants were positioned in the left of the back without any drug instillation (control group). In the PPL group, the capsule thickness (microm) and density (%) of collagen were significantly (p<0.0001) lower compared with the control group on days 35 and 90 postsurgery. Furthermore, in the PPL group, a significant reduction in myofibroblast count was observed on day 90 postsurgery (p<0.0001). In conclusion, a single dose of depot liposome-delivered prednisolone was effective at impairing capsule formation around the silicone implant. The results suggest a strong local and weak systemic effect of PPL on the fibrous tissue around silicone implants. To our knowledge, no study has yet assessed the effect of PPL on silicone breast implants.

Pocket delivery of one dose of Zafirlukast was effective in impairing capsule formation around the textured implant.

The perioperative use of atenolol caused a decrease in blood pressure and heart rate and decreased the incidence of expanding hematoma after rhytidectomy.

This article aims to describe the record type for first-time hospital admissions of 761 women at a single institution between 1997 and 2010 according to International Classification of Diseases, 10(th) revision, criteria, for mental and behavioral disorders due to psychoactive substance use (F10-F19). This cross-sectional study included a convenience sample of 4,736 patients in the Brazilian public health system, among whom 761 were women. Overall, the rate of alcohol-related hospitalizations decreased from 93.6% in 1997 to 50.9% in 2010. In contrast, the rate of crack cocaine-related hospitalizations increased in women from 2.8% in 1997 to 67.8% in 2010. The linear regression was R(2) = 0.8472. These data indicate a new trend in the pattern of psychoactive substance use in women.

The combination of subcutaneous flap rhytidectomy and SMAS plicature with fractional laser resurfacing plus hyaluronic acid injection is a safe procedure with low incidence of major complications and improves patient satisfaction.

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The paper focuses on the field life cycle and how new technology (including digital) and proactive, collaborative workflows can significantly optimize a field's production, with a focus on Brazil. Specifically, we discuss how, in the presalt, it is important to monitor casing integrity to identify salt creep and deformation as soon as possible. Proactive early identification of issues can accelerate the plugging and abandonment (P&A) decision at a stage where costs are reduced by avoidance of a more complex P&A caused by deformation of major completion components. Considering the complexity of a deepwater intervention, an innovative approach of through-tubing well surveillance was implemented, based on the third interface echo measurement provided by an advanced ultrasonic tool. The technique was deployed in some wells where the casing stress analysis indicated there was a risk of collapse, providing valuable information about casing and tubing integrity, as well as precise identification of annulus content. The paper intends to present local examples of the logs run, collaboration among technical experts, and the decisions made. The scope extends beyond the initial production period to maximizing production, when it is necessary to consider production issues as well as well integrity issues. The paper proposes that conventional KPIs may not measure the real intervention performance and can indeed detract from an optimal outcome. Most of the wells assessed were found with their integrity preserved, and therefore the production and/or injection, could continue. Where integrity issues were identified, the data gathered were used to redefine the intervention, allowing a safe temporary well suspension, assertive P&A planning, reducing the uncertainties, and facilitating communication with the regulatory agency. The paper will then discuss, during the barrel chasing phase of the field's life, how a better, collaborative alignment of the interests of all shareholders to the outcome of increased production can be achieved. Case studies reflect application of the technique in Brazil. The study demonstrates how to achieve the optimized field life cycle. New technology, including advanced digital workflows, has been applied to the challenge of well integrity assessment to examine casing deformation in Brazil. This has proven extremely important in early identification of issues to enable the most cost-effective remediation. New collaborative workflows initiated after well integrity optimization optimize production from existing well infrastructure to extend the field life cycle.