BackgroundOsteoarthritis is a chronic disease with a multifactor etiology involving changes in bone alignment, cartilage, and other structures necessary to joint stability. There is a need to investigate therapeutic resources that combine different wavelengths as well as different light sources (low-level laser therapy and light-emitting diode therapy) in the same apparatus for the treatment of osteoarthritis. The aim of the proposed study is to analyze the effect of the incorporation of phototherapy into a therapeutic exercise program for individuals with osteoarthritis of the knee.Methods/DesignA double-blind, controlled, randomized clinical trial will be conducted involving patients with osteoarthritis of the knee. Evaluations will be performed using functional questionnaires before and after the treatment protocols, in a reserved room with only the evaluator and participant present, and no time constraints placed on the answers or evaluations. The following functional tests will also be performed: stabilometry (balance assessment), dynamometry (muscle strength of gluteus medius and quadriceps), algometry (pain threshold), fleximeter (range of motion), timed up-and-go test (functional mobility), and the functional reach test. The participants will then be allocated to three groups through a randomization process using opaque envelopes: exercise program, exercise program + phototherapy, or exercise program + placebo phototherapy, all of which will last for eight weeks.DiscussionThe purpose of this randomized clinical trial is to analyze the effect of the incorporation of phototherapy into a therapeutic exercise program for osteoarthritis of the knee. The study will support the practice based on evidence to the use of phototherapy in individuals with a diagnosis of osteoarthritis of the knee. Data will be published after the study is completed.Trial registrationThe protocol for this study has been submitted to Clinical Trials, registration number NCT02102347, on 29 March 2014.
O objetivo neste estudo foi analisar a qualidade de vida de cuidadores informais de pacientes com seqüelas causadas por doenças neurológicas, especialmente as lesões medulares e os acidentes vasculares encefálicos (AVE), que causam grande impacto na vida desses cuidadores. Participaram da pesquisa 20 indivíduos divididos em dois grupos: o primeiro grupo, formado por cuidadores informais de pacientes acometidos por AVE ou lesão medular, e o segundo – o grupo controle – por indivíduos (n=11) que não trabalhavam na área da saúde. Todos os participantes foram submetidos à avaliação da qualidade de vida por meio da aplicação do questionário Short-Form 36 (SF-36). Os resultados obtidos permitiram verificar redução significativa dos valores de escores de 7 dos 8 domínios do SF-36, no grupo dos cuidadores informais, em comparação aos indivíduos controle. Conclui-se, dessa forma, que os cuidadores informais apresentaram uma redução da qualidade de vida quando comparados aos indivíduos do grupo controle.
This study aimed to determine whether photobiomodulation therapy (PBMT) in diabetic rats subjected to high-intensity exercise interferes with the expression of the oxidative stress marker in the gastrocnemius muscle. Twenty-four male Wistar rats were included in this study comprising 16 diabetic and eight control rats. The animals were allocated into three groups-control, diabetic fatigue, and diabetic PBMT fatigue groups. Diabetes was induced via the intraperitoneal administration of streptozotocin (50 mg/kg). We subsequently assessed blood lactate levels and PBMT. The animals of the diabetic fatigue group PBMT were irradiated before the beginning of the exercises, with dose of 4 J and 808 nm, were submitted to treadmill running with speed and gradual slope until exhaustion, as observed by the maximum volume of oxygen and lactate level. The animals were euthanized and muscle tissue was removed for analysis of SOD markers, including catalase (CAT), glutathione peroxidase (GPx), and 2-thiobarbituric acid (TBARS) reactive substances. CAT, SOD, and GPx activities were significantly higher in the diabetic PBMT fatigue group (p< 0.05) than in the diabetic fatigue group. Outcomes for the diabetic PBMT fatigue group were similar to those of the control group (p > 0.05), while their antioxidant enzymes were significantly higher than those of the diabetic fatigue group. PBMT mitigated the TBARS concentration (p > 0.05). PBMT may reduce oxidative stress and be an alternative method of maintaining physical fitness when subjects are unable to perform exercise. However, this finding requires further testing in clinical studies.
BackgroundType 2 diabetes, also known non-insulin-dependent diabetes, is the most prevalent type of the disease and involves defects in the secretion and action of insulin. The aim of the proposed study is to evaluate the efficacy of pre-exercise low-level laser therapy (LLLT) on muscle performance of the quadriceps femoris in individuals with type 2 diabetes.Methods/DesignA double-blind, randomized, controlled clinical trial will be carried out in two treatment phases. In the first phase, quadriceps muscle performance will be evaluated using an isokinetic dynamometer and the levels of creatine kinase and lactate dehydrogenase (biochemical markers of muscle damage) will be determined. The participants will then be allocated to four LLLT groups through a randomization process using opaque envelopes: Group A (4 Joules), Group B (6 Joules), Group C (8 Joules) and Group D (0 Joules; placebo). Following the administration of LLLT, the participants will be submitted to an isokinetic eccentric muscle fatigue protocol involving the quadriceps muscle bilaterally. Muscle performance and biochemical markers of muscle damage will be evaluated again immediately after as well as 24 and 48 hours after the experimental protocol. One week after the last evaluation the second phase will begin, during which Groups A, B and C will receive the LLLT protocol that achieved the best muscle performance in phase 1 for a period of 4 weeks. At the end of this period, muscle performance will be evaluated again. The protocol for this study is registered with the World Health Organization under Universal Trial Number U1111-1146-7109.DiscussionThe purpose of this randomized clinical trial is to evaluate the efficacy of pre-exercise LLLT on the performance of the quadriceps muscle (peak torque, total muscle work, maximum power and fatigue index – normalized by body mass) in individuals with DM-2. The study will support the practice of evidence-based to the use of LLLT in improving muscle performance in Individuals with DM-2. Data will be published after the study is completed.
Introdução: A Síndrome de Fibromialgia (SF) é caracterizada pela presença de dor muscular difusa, tender points, fadiga e distúrbios no sono. Objetivos: Neste estudo, analisou-se o efeito do ultrassom terapêutico (US), na dor, rigidez, quantidade de tender points, qualidade do sono e de vida de quatro voluntárias com SF. Método: As pacientes foram avaliadas pré e pós-tratamento para verificação da quantidade de tender points positivos, da Qualidade de Vida utilizando o questionário Short Form -36 (SF-36), e da qualidade do sono, dor e rigidez, com auxílio de Escalas Visuais Analógicas (EVAs). Realizaram-se 10 sessões de tratamento utilizando o US (1 MHz, pulsado a 20%, intensidade 0,5w/cm2, 1 minuto em cada tender point). Resultados: Os resultados evidenciaram melhora significativa da dor, qualidade do sono e de vida além de redução de tender points positivos após o tratamento. Conclusão: O US induziu a melhora de sintomatologia, qualidade do sono e de vida das pacientes com SF.
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