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Sulfur vacant sites in MoS2 nanosheets (NSs) have been confirmed to be effective in reacting with thiol molecules in solution. However, little-to-no information is known about the molar ratio of the remaining thiols and the produced disulfides in the reaction of MoS2 NSs and thiol molecules. Additionally, the MoSe2 NS-mediated conversion of thiol molecules has not been explored at present. Herein, we conducted a comparative study regarding the very-few-layer (VFL; layer number ∼ 3) MoS2 and VFL-MoSe2 NS-induced conversion of glutathione (GSH) to GSH disulfide (GSSG) in phosphate-buffered saline and the oxidation of GSH in live cells. Compared to traditional colorimetric assays for determining the percentage loss of GSH, liquid chromatography and mass spectroscopy were introduced to confirm and accurately quantify the molar ratio of the remaining GSH to produced GSSG from the reaction of the present VFL-MoS2 and VFL-MoSe2 NSs with GSH at pH 4.0–10 and 25–70 °C. The produced GSSG molecules were the leading product in the above-discussed reaction, and most of them were liberated into the solution rather than adsorbed on the NS surface. Additionally, it was found that VFL-MoSe2 converted more efficiently GSH to GSSG than VFL-MoS2 NSs. These findings were also valid for 5-thio-2-nitrobenzoic acid, which was well-suited to evaluate the difference in the rate constant of thiol conversion among the proposed two-dimensional NSs. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide cell viability assay, GSH-specific fluorescent probe, and live/dead cell staining kit demonstrated that the cellular cytotoxicity of the proposed two-dimensional NSs was highly correlated with the oxidation of intracellular GSH. The presence of selenocysteine filling selenium vacancies in VFL-MoSe2 NSs suppressed the conversion of GSH to GSSG in solution and the oxidation of GSH in live cells. Our findings point out that the reaction pathway of MoS2 and MoSe2 NSs with thiols not only involves vacant site repairing and thiol conjugation but also includes thiol dimerization.

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The phosphorescence of solid-state carbon dots (CDs) has been demonstrated to be susceptible to water molecules. However, solution-based CDs have been rarely exploited for phosphorescent detection of trace amounts of...

In this study, we have used the one-pot polycondensation method to prepare novel 2D conjugated microporous polymers (Th-F-CMP) containing thiophene (Th) and fluorene (Fl) moieties through the Suzuki cross-coupling reaction. The thermogravimetric analysis (TGA) data revealed that Th-F-CMP (Td10 = 418 °C, char yield: 53 wt%). Based on BET analyses, the Th-F-CMP sample displayed a BET specific surface area of 30 m2 g−1, and the pore size was 2.61 nm. Next, to show the effectiveness of our study, we utilized Th-F-CMP as a fluorescence probe for the selective detection of Fe3+ ions at neutral pH with a linear range from 2.0 to 25.0 nM (R2 = 0.9349). Furthermore, the electrochemical experimental studies showed that the Th-F-CMP framework had a superior specific capacity of 84.7 F g−1 at a current density of 0.5 A g−1 and outstanding capacitance retention (88%) over 2000 cycles.

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The embedding of MoS2 quantum dots in polyvinyl alcohol matrices produces long afterglow phosphorescent materials.