“…24 ALP was reported as an important biomarker for the diagnosis of various diseases, such as bone diseases, breast and prostatic cancer, diabetes, liver dysfunction, intestinal diseases, heart failure, etc. 25 Many uorescent probes have been successfully used for ALP detection, including folic acid functionalized molybdenum oxide quantum dots (FA-MoO x QDs), 26 L-histidine (His) functionalized zeolite imidazole framework ZIF-8 (His@-ZIF-8), 27 copper nanoclusters (Cu NCs), 28 MoS 2 QDs, 29 and ZnS QDs. 30 However, these probes suffer from the drawbacks of poor photostability and multistep procedures, suggesting the necessity to develop a plain uorescent probe for ALP detection through uorescence sensing.…”