Optical nanoprobes for aminothiols sensing in real-world samples

Madhu, Manivannan; Santhoshkumar, S.; Tseng, Wei‐Bin; Tseng, Wei‐Lung

doi:10.1016/j.snr.2022.100123

Cited by 6 publications

(7 citation statements)

References 193 publications

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“…Significantly, the detection limit and linear detection range obtained in the present work fell within the range of clinical interest for the GSH concentration analysis of human urine and plasma samples. 54,55…”

Section: Resultsmentioning

confidence: 99%

Gold(i) N-heterocyclic carbene complexes with tunable electronic properties for sensitive colorimetric detection of glutathione

Zhang

et al. 2023

Mater. Chem. Front.

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Section: Resultsmentioning

confidence: 99%

Gold(i) N-heterocyclic carbene complexes with tunable electronic properties for sensitive colorimetric detection of glutathione

Zhang

et al. 2023

Mater. Chem. Front.

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“…CDs-based fluorescent assays of biothiols are equal with inorganic, organic, and hybrid nanoprobes in low toxicity and biocompatibility when the analyte detection is conducted in an aqueous environment [ 153 , 154 , 155 ].…”

Section: Advantagesmentioning

confidence: 99%

Review on Carbon Dot-Based Fluorescent Detection of Biothiols

Shellaiah

Sun

2023

Biosensors

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Biothiols, such as cysteine (Cys), homocysteine (Hcy), and glutathione (GSH), play a vital role in gene expression, maintaining redox homeostasis, reducing damages caused by free radicals/toxins, etc. Likewise, abnormal levels of biothiols can lead to severe diseases, such as Alzheimer’s disease (AD), neurotoxicity, hair depigmentation, liver/skin damage, etc. To quantify the biothiols in a biological system, numerous low-toxic probes, such as fluorescent quantum dots, emissive organic probes, composited nanomaterials, etc., have been reported with real-time applications. Among these fluorescent probes, carbon-dots (CDs) have become attractive for biothiols quantification because of advantages of easy synthesis, nano-size, crystalline properties, low-toxicity, and real-time applicability. A CDs-based biothiols assay can be achieved by fluorescent “Turn-On” and “Turn-Off” responses via direct binding, metal complex-mediated detection, composite enhanced interaction, reaction-based reports, and so forth. To date, the availability of a review focused on fluorescent CDs-based biothiols detection with information on recent trends, mechanistic aspects, linear ranges, LODs, and real applications is lacking, which allows us to deliver this comprehensive review. This review delivers valuable information on reported carbon-dots-based biothiols assays, the underlying mechanism, their applications, probe/CDs selection, sensory requirement, merits, limitations, and future scopes.

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“…In the past few years, gold nanoclusters (AuNCs) have appeared as potential nanomaterials and have received substantial attention due to their distinctive catalytic, magnetic, electrical, and optical features. 21–26 Among these properties, the visible to near-infrared fluorescence of AuNCs is the most attractive, mainly because fluorescence-related technologies are widely used in light-based devices, in vivo and in vitro imaging, and biosensors. 27–29 AuNCs exhibit enhanced photostability, rendering them highly suitable for extended periods of fluorescence sensing.…”

Section: Introductionmentioning

confidence: 99%