Gold nanocluster-based fluorescent sensors for<i>in vitro</i>and<i>in vivo</i>ratiometric imaging of biomolecules

Santhoshkumar, S.; Madhu, Manivannan; Tseng, Wei‐Bin; Tseng, Wei‐Lung

doi:10.1039/d3cp02714g

Cited by 8 publications

(3 citation statements)

References 96 publications

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“…Ratiometric measurements are based on self-calibration of signal intensity by recording two or more signal fluctuations induced by analytes, where one signal can be used as internal standard to normalize the others. Ratiometric measurements are independent of various analyte-independent confounding factors, which contributes to more accurate and reliable quantification [30].…”

Section: Optimization Of Working Condition Of Ratiometric Fluorescent...mentioning

confidence: 99%

“…Currently, most fluorescent probes are constructed based on the mechanism of intramolecular charge transfer (ICT), fluorescence resonance energy transfer (FRET), or PET [30]. However, the intramolecular conjugated structure composed of electron donor and electron acceptor is necessary for ICT, and the emission will also shift either red or blue.…”

Section: Possible Mechanism Of Fluorescence Quenching Of Induced By D...mentioning

confidence: 99%

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Ratiometric fluorescence detection of dopamine based on copper nanoclusters and carbon dots

Meng,

Sun,

et al. 2024

Nanotechnology

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Nanoclusters for fluorescence detection are generally comprised of rare and expensive noble metals, and the nanoclusters based on more affordable transition metal have attracted increasing attention. This study designed a ratiometric fluorescent probe to detect dopamine (DA), an important neurotransmitter. With carbon dots encapsulated within silica (CDs@SiO2) as the reference, the emitted reference signal was almost unchanged due to the protection of inert silicon shell. Meanwhile, copper nanoclusters modified with 3-aminophenyl boronic acid (APBA-GSH-CuNCs) provided the sensing signal, in which the phenylboric acid could specifically recognize the cis-diol structure of DA, and caused the fluorescence quenching by photoinduced electron transfer. This dual emission ratiometric fluorescent probe exhibited high sensitivity and anti-interference, and was able to selectively responded to DA with a linear range of 0~1.4 mM, the detection limit of 5.6 nM, and the sensitivity of 815 mM-1. Furthermore, the probe successfully detected DA in human serum samples, yielding recoveries ranging from 92.5% to 102.7%. Overall, this study highlights the promising potential of this ratiometric probe for detecting DA.

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Section: Optimization Of Working Condition Of Ratiometric Fluorescent...mentioning

confidence: 99%

Section: Possible Mechanism Of Fluorescence Quenching Of Induced By D...mentioning

confidence: 99%

Ratiometric fluorescence detection of dopamine based on copper nanoclusters and carbon dots

Meng,

Sun,

et al. 2024

Nanotechnology

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“…For example, protein-stabilized Au NCs with great biocompatibility have been widely used for bioimaging, biosensing, and therapy [20]. In addition, thiolatecapped Au NCs with a precise gold atom number also show extensive applications in both in vitro and in vivo studies [21]. We have witnessed significant advancements in the development of Au NC-based sensing probes and therapeutic agents that exhibit improved sensitivity, selectivity, and stability.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Gold Nanocluster-Based Biosensing and Therapy: A Review

Yang,

Hou,

Wei

et al. 2024

Molecules

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Gold nanoclusters (Au NCs) with bright emission and unique chemical reactivity characters have been widely applied for optical sensing and imaging. With a combination of surface modifications, effective therapeutic treatments of tumors are realized. In this review, we summarize the recently adopted biosensing and therapy events based on Au NCs. Homogeneous and fluorometric biosensing systems toward various targets, including ions, small molecules, reactive oxygen species, biomacromolecules, cancer cells, and bacteria, in vitro and in vivo, are presented by turn-off, turn-on, and ratiometric tactics. The therapy applications are concluded in three aspects: photodynamic therapy, photothermal therapy, and as a drug carrier. The basic mechanisms and performances of these systems are introduced. Finally, this review highlights the challenges and future trend of Au NC-based biosensing and therapy systems.

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From synthesis to applications of biomolecule-protected luminescent gold nanoclusters

Qiu,

Ahmad,

et al. 2024

Anal Bioanal Chem

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Gold nanocluster-based fluorescent sensors forin vitroandin vivoratiometric imaging of biomolecules

Abstract: Gold nanoclusters (AuNCs) are highlighted as potential nanomaterials for ratiometric fluorescent probes due to their size- and structure-related tunable fluorescence wavelengths, biocompatibility, and resistance to photobleaching properties. Dual-emission AuNC-based fluorescent...

Cited by 8 publications

References 96 publications

Ratiometric fluorescence detection of dopamine based on copper nanoclusters and carbon dots

Ratiometric fluorescence detection of dopamine based on copper nanoclusters and carbon dots

Recent Advances in Gold Nanocluster-Based Biosensing and Therapy: A Review

From synthesis to applications of biomolecule-protected luminescent gold nanoclusters

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