poly((N-(4-((E)-3oxo-3-(10H-phenothiazin-8-yl) prop-1-enyl) phenyl) acrylamide), were synthesized by Claisen-Schmidt condensation reaction, followed by ultrasonic irradiation reduction. The synthesized polymers were characterized by Fourier transform infrared spectroscopy, 1 H nuclear magnetic resonance, and 13 C nuclear magnetic resonance spectroscopic technique. The newly synthesized polymers have been screened for antibacterial and antifungal activities by using resazurin reduction assay method, and the resulting polyacrylamides showed promising activity against various tested bacteria and fungi. Among the polymers, poly((N-(4-((E)-3-oxo-3-(10H-phenothiazin-8-yl) prop-1-enyl) phenyl) acrylamide) and poly((N-(4-((E)-3-(1H-indol-3-yl)-3-oxoprop-1-enyl) phenyl) acrylamide) exhibited better antifungal and antibacterial activities than poly ((N-(4-((E)-3-(naphthalen-6-yl)-3-oxoprop-1-enyl) phenyl) acrylamide), whereas all the polymers do not show any sign of antibacterial and antifungal activity against Streptococcus faecalis and Candida glabrata.
A photocrosslinkable polycyclic chalcone-based acrylamide has been synthesized by Claisen-Schmidt condensation reaction and then polymerized via free radical polymerization technique using azobisisobutyronitrile (AIBN) as an initiator. The resulting polymers have been characterized by FT-IR, 1 H-NMR and 13 C-NMR analytic techniques. The molecular weights of the polymers were determined by gel permeation chromatography. The thermal properties of synthesized polymers were characterized by TGA analysis, and the obtained results show good thermal and thermo-oxidative stability which is required for a negative photo resist. The high flame-retardant properties are calculated from limiting oxygen index (LOI) values and are found to be 36.9 and 32.0 for naphthyl and anthryl chalcone-based polymers, respectively. The experimentally determined LOI values of polymers (PMNPA and PAPA) are 34.3 and 30.2, respectively, and the values are closer to theoretically found LOI values. However, the cone calorimetry of flame-retardant PMNPA only showed a slight decrease in peak of heat release rate (PHRR) and total heat release (THR) compared to PAPA but the ignition time (TTI) of PMNPA is slightly higher than PAPA. The photocrosslinking properties of the polymers were investigated by UV spectroscopy technique and were found that with the increase in number of aromatic rings, the rate of crosslinking decreases. Thus polyacrylamides are useful in photolithography technology as well as flame-retardant property in electrical appliances.
Biologically active chalcone-based acrylamide monomers were synthesized via the Claisen-Schmidt condensation and polymerized by a free radical polymerization technique using azobisisobutyronitrile as an initiator. The newly synthesized polymers were characterized by FT-IR, 1 H NMR, and 13 C NMR analytic techniques. Thermal stability of the polymers was characterized by thermogravimetric analysis. The antimicrobial activity of polyacrylamides (PMNPA, PAPA, and PFPA) was evaluated from the minimum inhibitory concentration values by the resazurin reduction assay method. It is found that the polymers PMNPA and PAPA exhibit good antibacterial and antifungal activities, whereas polymer PFPA shows only antifungal activity and does not show any sign of antibacterial activity. C 2015 Wiley Periodicals, Inc. Adv Polym Technol 2015, 0, 21606; View this article online at wileyonlinelibrary.com.
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