The paper highlights some of the most important Ayurvedic medicinal plants of North Eastern India having anticancer potential. A brief review of distribution and pharmacological study (both in vivo and in vitro) of ten Ayurvedic medicinal plants of the region published by various researchers is illustrated in this paper. The medicinal plants discussed here are Enhydra Fluctuans Lour (Sanskrit: Hilamochika), Ageratum conizoides Linn.
The present study was undertaken to evaluate the Maximum Tolerated Dose and No Observed Adverse Effect Level of Trayodashang guggulu (TG), an Ayurvedic classical formulation, in Wistar rats. TG was administered orally to Wistar rats in as single dose (2000 mg/kg body weight) in an acute toxicity study. Ninety days repeated dose oral toxicity (subchronic) study was carried out by using three dose levels (250, 500 and 1000 mg/kg body weight) administered orally daily for 90 consecutive days and derived from 28 days dose range-finding study. In acute and subchronic toxicity studies, animals were observed for general clinical signs, mortality, weekly body weight changes, weekly feed intake, weekly water intake, blood biochemical investigation, haematological parameters, and gross pathological and histological investigations. In an acute toxicity study, the dose level of 2000 mg/kg of TG was found to be safe when given at a single dose. In the dose rangefinding study and subchronic toxicity study TG was found to be safe at all tested dose levels. No significant changes in food and water consumption, haematological and blood biochemical parameters were noticed at any dose level in both studies. No major changes were noticed during histopathological evaluation in ninety days repeated dose oral toxicity study. The study concluded that the Maximum Tolerated Dose of TG was found at 2000 mg/kg body weight and the No Observed Adverse Effect Level was found at 1000 mg/kg in Wistar rats.
This study is carried out in a view to evaluate hypoglycaemic activity of stem bark extracts of Annona reticulata L. in streptozotocin induced diabetic rats. Oral administrations of petroleum ether, chloroform, ethyl acetate and ethanol extract of the plant stem bark up to 2000mg/kg body weight did not show any signs of toxicity and mortality in this study. In Oral Glucose Tolerance Test, administration of glucose (2.5g/k g,) produced significant change in blood glucose level of normal mice. Treatment with A. reticulata ethanolic extract (200 and 400mg/kg) and standard drug glibenclamide (10mg/kg.) significantly reduced serum glucose level in normal fasting, at 0min, 30min, 60min and 120min compared to normal c ontrol group. Ethanolic extract of the plant showed more significant blood glucose lowering activity at 400mg/kg dose level. But Petroleum ether, ethyl acetate and chloroform extracts of the plant did not show significant decrease in the blood glucose levels. So, in this study 400mg/kg o f ethanolic extract of A. reticulata was selected for the evaluation of anti-diabetic activity in streptozotocin induced diabetic rats. Oral administration of ethanolic plant extract of A. reticulata stem bark at 400mg/kg/day and standard drug Glibencamide for 15 consecutive days to streptozotocin induced diabetic rats significantly reversed decreased body weight, increased water consumption and increased fasting plasma glucose level in comparision to diabetic control animals. Phytochemical analysis of the plant sample showed the presence of different chemical compounds like alkaloids, flavanoides, Phenolic glycosides and lignans.
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