Dengue viruses are the most prevalent arthropod-borne viral diseases in humans, infecting 50-100 million people each year. Its serotypes are the most common causes of arboviral illness, putting half of the world's population at risk of infection. Because there is no vaccine or antiviral medicines, the only way to manage the disease is to reduce the Aedes mosquito vectors. DENV infection can be asymptomatic or cause a self-limiting, acute febrile illness with varying degrees of severity. High fever, headache, stomach discomfort, rash, myalgia, and arthralgia are the typical symptoms of dengue fever (DF). Thrombocytopenia, vascular leakage, and hypotension are symptoms of severe dengue, dengue hemorrhagic fever (DHF), and dengue shock syndrome (DSS). Systemic shock characterizes DSS, which can be deadly. Dengue virus infection pathogenesis is linked to a complex interaction between virus, host genes, and host immune response. Major drivers of disease vulnerability include host factors such as antibody-dependent enhancement (ADE), memory cross-reactive T cells, anti-DENV NS1 antibodies, autoimmunity, and genetic variables. The NS1 protein and anti-DENV NS1 antibodies were thought to be involved in the development of severe dengue. The progressive infection may change the cytokine response of cross reactive CD4+ T cells. The need for dengue vaccines that can generate strong protective immunity against all four serotypes is required. To create such vaccines, a thorough understanding of DENV adaptive immunity is required. Structural and functional research have shown that the degree of prM protein cleavage as well as the ensemble of conformational states sampled by virions influence DENV sensitivity to antibody-mediated neutralization, which has crucial implications for vaccine formulation.
Background and Objective: The objective of this study was to compare the prevalence of dental caries through the Decayed, Missing and Filled Teeth (DMFT) index of students belonging to the three different education systems of Pakistan in order to ascertain the baseline statistics for the Pakistani student population. Methods: A cross-sectional study was conducted during the year 2018 to record DMFT scores of students studying in madrassas, government and private schools of Rawalpindi and Islamabad. A total of 663 students underwent a DMFT evaluation by trained dentists following the consent of their parents. The results were analyzed by using one way ANOVA and post-hoc tests for comparing DMFT scores among the students of different school system using Statistical Package for Social Sciences (SPSS) version 23 and a P-value of <0.05 was taken as significant. Results: Madrassa group of students had the best DMFT scores; mean DMFT of 1.2 ± 1.9 whereas private school students had a mean DMFT of 2.17 ± 2.9 and Government school children had a mean DMFT score of 2.09 ± 2.08. While comparing the DMFT scores of madrassa students with government and private school students, statistically significant results were observed. Conclusion: Although an acceptable DMFT score was obtained for each of the three education systems; madrassa, government and private schools; the DMFT scores were the lowest for the madrassa students indicating best dental health in them.
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