BACKGROUND: Nomophobia (no-mobile-phone phobia) is a relatively new term that describes the growing fear and anxiety associated with being without a mobile phone.
Dengue viruses are the most prevalent arthropod-borne viral diseases in humans, infecting 50-100 million people each year. Its serotypes are the most common causes of arboviral illness, putting half of the world's population at risk of infection. Because there is no vaccine or antiviral medicines, the only way to manage the disease is to reduce the Aedes mosquito vectors. DENV infection can be asymptomatic or cause a self-limiting, acute febrile illness with varying degrees of severity. High fever, headache, stomach discomfort, rash, myalgia, and arthralgia are the typical symptoms of dengue fever (DF). Thrombocytopenia, vascular leakage, and hypotension are symptoms of severe dengue, dengue hemorrhagic fever (DHF), and dengue shock syndrome (DSS). Systemic shock characterizes DSS, which can be deadly. Dengue virus infection pathogenesis is linked to a complex interaction between virus, host genes, and host immune response. Major drivers of disease vulnerability include host factors such as antibody-dependent enhancement (ADE), memory cross-reactive T cells, anti-DENV NS1 antibodies, autoimmunity, and genetic variables. The NS1 protein and anti-DENV NS1 antibodies were thought to be involved in the development of severe dengue. The progressive infection may change the cytokine response of cross reactive CD4+ T cells. The need for dengue vaccines that can generate strong protective immunity against all four serotypes is required. To create such vaccines, a thorough understanding of DENV adaptive immunity is required. Structural and functional research have shown that the degree of prM protein cleavage as well as the ensemble of conformational states sampled by virions influence DENV sensitivity to antibody-mediated neutralization, which has crucial implications for vaccine formulation.
The coronavirus disease emerged at the end of 2019 from Wuhan, China, and ultimately resulted in pandemic. It is a single positive-sense RNA virus spreading from person to person through contact in any form. Bats are the natural hosts of the SARS-CoV-2 virus. SARS-CoV-2 has the largest genome as compared to all RNA virus present so far. Spike proteins are responsible for their entrance into the human body. Social distancing and quarantine resulted in the best possible prevention for the less transmission of coronavirus. We performed a narrative review to describe its origin, transmission, pathogenesis, clinical manifestation, social implications, future possibilities, treatment, and vaccination.
Introduction: In December 2019, China faced the COVID-19 outbreak. COVID-19 is a disease caused by the pathogen, SARS-CoV-2 which is a single stranded RNA virus that spreads person to person via direct contact or respiratory droplets. Since this disease has been found to be highly contagious, prevention from virus exposure seems to be a reasonable approach especially due to lack of an effective vaccination up till now. Our study is aimed at proposing the prophylactic strategies that can be implemented in Pakistan to help flatten the disease curve in order to provide more time for healthcare professionals to fight the disease better and to hopefully come up with an effective vaccination for long term disease control. Methods: We conducted a systematic literature review based on PRISMA guidelines. Only those articles were included which met the inclusion criteria. Results: The results gathered by the literature search suggested that due to the lack of any licensed vaccine or effective treatment, adopting personal and environmental protective measures, isolation and quarantine, and other community mitigation measures like temporary lockdown can help flatten the peak of the ongoing pandemic. Conclusion: Since there has not been any breakthrough in finding an effective vaccine, our review aims to devise an effective preventive strategy to curb this pandemic according to the present socio-economic conditions of Pakistan.
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