We used photoacoustics in order to image a vasculature cast, which was obtained from a Wistar rat. The main objective was to investigate the imaging quality and the performance of the beamforming algorithm. For these purposes, the specimen was measured in several Intralipid™ 10% solutions and it was scanned with scanning steps of 100, 200, and 300 μm. The measurements were performed with a disk-shaped detector, with PVDF as an active material and four fibers for the light delivery. From the recorded signals, three-dimensional images of the cast were constructed.
The visualization of the brain vascular system could be of great importance for studying its functionality and for diagnosing possible disorders. In this paper we report the use of photoacoustics for imaging brain perfusion on Albino rats in vivo and post mortem. The measurements on the animals were direct on the skin surface. The blood perfusion on skull cartilage was imaged and 2D slices were constructed by using a beamforming algorithm. From the images representation the Interactive Data Language (IDL, Research System Inc.) was used. We also investigated the possibility of using the Evans Blue dye as a substitute of blood for imaging brain structures in vitro. The breakdown of the dye under pulsed laser irradiation was studied and the energy under which this effect occurs was calculated for the wavelength of 532 nm.
Background and Objectives: The ability to correctly visualize the architectural arrangement of microvasculature is valuable to many diverse fields in medicine. In this study, we applied photoacoustics (PA) to obtain highresolution images of submillimeter blood vessels. Study Design/Materials and Methods: Short laser pulses are used to generate ultrasound from superficial blood vessels in several animal models. From these ultrasound waves the interior of blood vessels can be reconstructed. Results: We present results from a novel approach based on the PA principle that allows specific in vivo visualization of dermal blood vessels without the use of contrast agents or ionizing radiation. Conclusions: We show PA images of externalized blood vessels and demonstrate in vivo PA imaging of vasculature through layers of skin varying in thickness. Lasers Surg.
Photoacoustic ͑PA͒ signal generation can be used as the basis for a new medical tomographic technique. In this article, we present results, which have been obtained by applying the PA technique on animals and more specifically on Wistar rats. The primary goal was to investigate the possibility of using PA for monitoring the changes in the blood circulation. This was achieved by tracking the vessel position with one-dimensional scans and by monitoring the changes in the signal due to artificially induced changes in the blood circulation.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.