Photoacoustic imaging of blood vessels in tissues

Mul, F.F.M. de; Pilatou, Magdalena C.; Kolkman, R.G.M.; Hondebrink, Erwin; Steenbergen, Wiendelt

doi:10.1117/12.486606

Cited by 1 publication

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“…In the phantom study performed in [ 6 ], it was observed that in comparison to ultrasound (US) and mammography, the new laser optoacoustic imaging technique offers images with improved contrast for phantoms that were dense and uniform acoustically. Over time, with improvements in hybrid imaging technologies and advancements in image reconstruction algorithms, it became possible to use the PA effect for in vivo studies [ 10 , 11 , 12 ]. In the past few years, a significant evolution in PAI is evident, which will be further discussed in this paper with a focus on contrast agents used in in vivo PAI studies (refer to Figure 1 ).…”

Section: Introductionmentioning

confidence: 99%

Exogenous Contrast Agents in Photoacoustic Imaging: An In Vivo Review for Tumor Imaging

et al. 2022

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The field of cancer theranostics has grown rapidly in the past decade and innovative ‘biosmart’ theranostic materials are being synthesized and studied to combat the fast growth of cancer metastases. While current state-of-the-art oncology imaging techniques have decreased mortality rates, patients still face a diminished quality of life due to treatment. Therefore, improved diagnostics are needed to define in vivo tumor growths on a molecular level to achieve image-guided therapies and tailored dosage needs. This review summarizes in vivo studies that utilize contrast agents within the field of photoacoustic imaging—a relatively new imaging modality—for tumor detection, with a special focus on imaging and transducer parameters. This paper also details the different types of contrast agents used in this novel diagnostic field, i.e., organic-based, metal/inorganic-based, and dye-based contrast agents. We conclude this review by discussing the challenges and future direction of photoacoustic imaging.

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