Imaging of small vessels using photoacoustics: An in vivo study

Siphanto, Ronald I.; Kolkman, R.G.M.; Huisjes, Arjan; Pilatou, Magdalena C.; Mul, F.F.M. de; Steenbergen, Wiendelt; Adrichem, L.N.A. van

doi:10.1002/lsm.20100

Cited by 15 publications

(11 citation statements)

References 30 publications

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“…22 An amplitude image-a plot of the PA signal amplitude versus the scanned positions of the ultrasonic transducer-of a rabbit ear is shown in Fig. 3͑a͒, which shows the vasculature clearly.…”

Section: Resultsmentioning

confidence: 99%

Photoacoustic imaging of biological tissue with intensity-modulated continuous-wave laser

2008

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Abstract. We build a photoacoustic imaging system using an intensity-modulated continuous-wave laser source, which is an inexpensive, compact, and durable 120-mW laser diode. The goal is to significantly reduce the costs and sizes of photoacoustic imaging systems. By using a bowl-shaped piezoelectric transducer, whose numerical aperture is 0.85 and resonance frequency is 2.45 MHz, we image biological tissues with a lateral resolution of 0.45 mm, an axial resolution of 1 mm, and an SNR as high as 43 dB.

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Section: Resultsmentioning

confidence: 99%

Photoacoustic imaging of biological tissue with intensity-modulated continuous-wave laser

2008

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“…C) KEY STRENGTHS AND LIMITATIONS. One of the main advantages of PAI is its depth of penetration (ϳ6 mm to 5 cm), which is superior to that of most optical techniques (388). Additionally, the spatial resolution of PAI is not adversely affected by increases in depth of penetration, as is typically the case with some other optical modalities and US.…”

Section: Photoacoustic Imagingmentioning

confidence: 99%

“…These IR light pulses lead to a slight localized heating of the tissue causing thermoelastic expansion and the subsequent production of ultrasound waves. The resulting acoustic waves can be detected on the skin surface, and by measuring the wave's amplitude and the time of arrival, the structure of blood vessels can be determined (388). It is important to note that the input source does not need to be IR light, but can also be other forms of energy, including radiofrequency.…”

Section: Photoacoustic Imagingmentioning

confidence: 99%

A Molecular Imaging Primer: Modalities, Imaging Agents, and Applications

James

Gambhir

2012

Physiological Reviews

942

954

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Molecular imaging is revolutionizing the way we study the inner workings of the human body, diagnose diseases, approach drug design, and assess therapies. The field as a whole is making possible the visualization of complex biochemical processes involved in normal physiology and disease states, in real time, in living cells, tissues, and intact subjects. In this review, we focus specifically on molecular imaging of intact living subjects. We provide a basic primer for those who are new to molecular imaging, and a resource for those involved in the field. We begin by describing classical molecular imaging techniques together with their key strengths and limitations, after which we introduce some of the latest emerging imaging modalities. We provide an overview of the main classes of molecular imaging agents (i.e., small molecules, peptides, aptamers, engineered proteins, and nanoparticles) and cite examples of how molecular imaging is being applied in oncology, neuroscience, cardiology, gene therapy, cell tracking, and theranostics (therapy combined with diagnostics). A step-by-step guide to answering biological and/or clinical questions using the tools of molecular imaging is also provided. We conclude by discussing the grand challenges of the field, its future directions, and enormous potential for further impacting how we approach research and medicine.

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“…In contrast to optical methods, the spatial resolution in PA imaging is limited by the pressure detection. An optimization of this key parameter for any imaging technique was achieved by R. I. Siphanto et al by use of piezo-active ring sensors with a diameter of 200 µm 5,10 . The application of ring sensors and the advantages concerning directivity are investigated in several publications [11][12][13][14][15] .…”

Section: Introductionmentioning

confidence: 99%

Design and characterization of a highly directional photoacoustic sensor probe

Haisch¹,

Hoffmann²

2006

SPIE Proceedings

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We present design and comprehensive characterization of a versatile, small-scale photoacoustic sensor stick. Due to its optimized forward-looking directional characteristic, it is a valuable tool for spatially resolved PA depth scanning and 3D imaging. The pencil-formed, optical fiber-coupled sensor has a diameter of only 6 mm, with a length of 15 cm. For characterization of its fundamental parameters, we applied a pulsed frequency-doubled Nd:YAG laser (532 nm) with a pulse repetition rate of 10 Hz. Different designs of the sensor tip are compared. We present a full characterization of the qualities of the system as imaging tool, i.e. lateral and depth resolution in dependence on light absorption and scattering properties of the samples as well as of the surrounding matrix. Specially tailored phantoms are introduced for these experiments. The phantoms in combination with a xy-scanning stage are applied to produce 2D and 3D images with the sensor. The imaging properties of the endoscope are explored by several methods of characterization. We test the sensitivity to absorbing structures of different size and absorptivity, which can be summarized as contrast. Finally, we present first tomographic images of tissue phantoms resembling the optical properties of human tissue.

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Imaging of small vessels using photoacoustics: An in vivo study

Cited by 15 publications

References 30 publications

Photoacoustic imaging of biological tissue with intensity-modulated continuous-wave laser

Photoacoustic imaging of biological tissue with intensity-modulated continuous-wave laser

A Molecular Imaging Primer: Modalities, Imaging Agents, and Applications

Design and characterization of a highly directional photoacoustic sensor probe

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