The clinical efficiency of the an bio c is determined by its distribu on in organs and ssues, the ability to penetrate the physiological and pathological barriers of the body. The ar cle presents the results from a study of the intake, distribu on, and excre on of doxycycline hyclate -the ac ve substance of the an bio c pollodoxin from the body of broiler chickens (the Cobb-500 cross) with ornithobacteriosis.It has been established that 24 hours a er the pollodoxin solu on applica on in broiler chickens with ornithobacteriosis, the highest content of its ac ve substance (doxycycline hyclate) was found in the lungs, liver, slightly less -in the kidneys, and least -in the heart and pectoral muscles. A er 48 and 72 hours, the content of doxycycline hyclate increases in the liver, kidneys, heart, and pectoral muscles compared to 24 hours, while in the lungs decreases slightly a er 48 hours and does not differ from it a er 72 hours. At 96 hours, the content of doxycycline hyclate in the kidneys, lungs, and pectoral muscles reaches maximum values; in the liver it is smaller than the previous one (72 hours), while in the heart it does not differ from it. Doxycycline hyclate does not show cumula ve proper es and "organ affilia on" during 96 hours of entry into the body of broiler chickens with ornithobacteriosis. A er 24 hours of discon nua on of pollodoxin use (120 hours of the experiment), the content of doxycycline hyclate
The changes of calcium, phosphorus, magnesium foals for hypercalcitoninemia was studied. In the first months of life calcium metabolism were altered. During the first month of life the majority of foals (85.7 percent) is hypocalcemia. Obviously, it is physiological, because in this period of life calcitonin promotes in osteocytes inhibition of enzymes that break down bone tissue to ensure the consolidation of the skeleton. In later life foals for hypercalcitoninemia hypocalcemia was observed less in one - and two-month old she was found in 57.1% of the foals; in three - to five-month old – at 42.9%. In the six-month old foals, values of total calcium in blood serum were within the physiological range (2.15–of 2.63 mmol/l). Relatively ionized calcium, its content in foals for hypercalcitoninemia was practically the same during the whole period of studies (0.96 ± 0.019 mmol/l in first day of life – 1.0 ± 0.014 mmol/l at six months of age). The proportion of the ionized form of macroelements to total calcium was stable and ranged from 48.8 per cent after the birth to 47.0% in 5 months old. Only six-month foals she was the lowest and amounted to 43.0% of the content of total calcium in serum. The other macroelements – phosphorus and magnesium in foals with hypercalcitoninemia were not significantly different from animals with physiological quantities of the hormone. In particular, the content of phosphorus, regardless of age, almost all animals were within the range of 0.9 to 1.18 mmol/l (only in some animal figures were less – 0.81–0.76 mmol/l). The content of magnesium in the blood serum of foals with hypercalcitoninemia was in the range of 0.91 – of 1.16 mmol/l.
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