Sponge-derived fungi have attracted recent attention due to its important source of interesting biologically active compounds. In our previous study, we have obtained 13 fungi from marine sponge Neopetrsiachaliniformis. Among them, only Aspergillus nomius NC06 showed cytotoxic activity with the percentage of viability113.9 % and 70.31 % of Vero cell and WiDr colon cancer cell, respectively. This study aimed to isolate the cytotoxic compound from the ethyl acetate extract of N. nomius NC06 using chromatography method. A total of 5 fractions of the extract obtained using vacuum liquid chromatography. These fractions were tested against HCT 116 colon cancer cell and ten human pathogenic bacteria. Fraction II, III, IV, and V showed cytotoxic activity with IC 50 of 5. 28, 15.82, 10.27, and 45.57 µg/mL, respectively. In antibacterial testing, fraction II and III were potential because of their ability to inhibit the growth of ten pathogenic bacteria with the diameter of inhibition zone more than 12 mm.
A t global level many species of eatable mushrooms have been used for diet and medication purposes. Mushroom is the best from nutrition point of view concerning human health, diet, (Salehi and Kashaninejad 2016;Lebesi and Tzia, 2011) and its can also be used for hindrance of infection Mushroom basically is the variety of molds which frequently produce in cool areas and it frequently spread through spores to the different places. Mushroom is useful for diet manufactured goods which are utilized into raw forms and it also used into different food products through process of cooking. Recently, mushroom is Abstract | At global level many species of eatable mushrooms have been used for diet and medication purposes. In addition to its dietetic value mushroom have many medicinal importance because mushroom is used against several viral, bacterial and cancer diseases. Mushroom powder also used to reduce blood pressure and increase resistance of person against many diseases. Keeping in perspective the position of dietary and medicinal values of mushroom in this research mushroom powder was added into muffins to improve nutritious and dietetic status of muffin. To achieve desired objective mushroom powder was mixed with wheat flour to improve sensory attributes of muffins. The proximate analysis of mushroom based powder and wheat flour was also performed. After this loaf weight and volume, structural examination, sensual attributes of muffin were also performed. The effect of mushroom powder on moisture, crude protein crude fat and nitrogen free extract of muffin were non-significant and effect on ash and crude fiber were significant when 0%, 10%, 20%, 30% and 40% mushroom powder based muffin were prepared. The effect of mushroom powder supplementations on loaf weight of muffin was significant and resulted in gradual decrease. However, the effect on loaf volume of muffins was non-significant. The effects of mushroom powder on texture and color value of muffin were highly significant. The results of sensory evaluation showed that muffin prepared with 10% mushroom powder have high sensory score while muffins prepared with 40% mushroom powder had very low sensory score.
166 Background: Recently, there has been a breakthrough in the treatment and disease control of HER-2 positive mCRC using Trastuzumab (TRA) +Tyrosine Kinase inhibitor (TKI) regimens and regimens with trastuzumab based antibody drug conjugates (ADCs). Methods: A total of 14 randomized controlled trials and single arm clinical trials were collected from PubMed, Cochrane library, and Embase. 7 trials were excluded for being duplicate, irrelevant or because of lack of response from the trial researchers. Data from the remaining 7 articles was extracted either from the full publication or from researchers for undergoing studies. Trials using similar drug combinations were added up and results were reported cumulatively. Results: The data demonstrate an ORR of 30% or greater with the ADC, TRA deruxtecan or TRA+Tucatinib regimen with the Tucatinib combination being the most efficacious (38.10%), followed closely by the Deruxtecan ADC (36.99%). Promising disease control rate (DCR) was observed with all the combinations with TRA-Ematasin + Pertuzumab leading the charts (77.40%). TRA-Lapatinib provided the longest PFS (16.75 months) followed by TRA-Tucatinib (8.2 months) (Table). Most common treatment related adverse events (AEs) were fatigue, nausea, vomiting, diarrhea and dermatitis. More nausea/vomiting reported with TRA-deruxtecan (64.4%), while more diarrhea reported with TRA-lapatinib (81%) and TRA-tucatinib (52.3%). Dermatitis was reported mostly with TRA-lapatinib (44%) and TRA-tucatinib (17.4%). Conclusions: Our analysis shows that combination treatment with TRA-Deruxtecan and TRA-tucatinib are associated with the highest ORR and DCR in HER2+ mCRC. Long term data are needed to define clinical efficacious based on survival endpoints.[Table: see text]
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