Impacts of geogenic and anthropogenic sources change seriously quality of groundwater. Inferior groundwater quality directly affects the human health, agricultural output and industrial sector. The aim of the present study is to evaluate the groundwater quality for drinking purpose and also to identify the pollutants responsible for variation of chemical quality of groundwater, using pollution index of groundwater (PIG). Groundwater samples collected from a rural part of Telangana State, India, were analyzed for pH, total dissolved solids (TDS), calcium (Ca 2+), magnesium (Mg 2+), sodium (Na +), potassium (K +), bicarbonate (HCO − 3), chloride (Cl −), sulfate (SO 2− 4), nitrate (NO − 3) and fluoride (F −). The groundwater is characterized by Na + and HCO − 3 ions. The values of TDS
A Novel Schiff base as ON donor was synthesized by green methodology by condensation of 2-hydroxyacetophenone with Furfurylamine via microwave assisted reaction in fruit juice medium. Thus an efficient, green, cost-effective and eco-friendly method has been developed, using some common fruit juices as current approach of synthesizing Schiff base which has given a new direction in the field of green chemistry. This method was also compared with conventional method and grinding method for determination of production efficiency and production economic. The Schiff base was characterized based on the results obtained from CHN analysis, NMR, FTIR, LCMS and electronic spectral data. The geometry of the Schiff base was evaluated using molecular calculation with Argus lab software. The Schiff base ligand was tested for antibacterial activity against Gram positive bacteria Staphylococcus aureus and Bacillus subtilis and Gram negative bacteria Escherichia coli and Pseudomonas aeruginosa, and antifungal activity against Fusarium oxysporum and Fusarium recini, where the ligand showed good biological activity.
The field of nanotechnology is one of the most active research areas in modern material science. Nanoparticles exhibit new and improved properties based on specific characteristics such as size, distribution and morphology. Nanoparticles, because of their small size, have distinct properties compared to the bulk form of the same material, thus offering many new developments in the fields of biosensors, biomedicine and bionanotechnology. Nanotechnology is also being utilized in medicine for diagnosis, therapeutic drug delivery and the development of
Alangium salviifolium root was screened for phytochemical and anti-inflammatory properties. The percentage inhibition of carrageenan induced paw oedema was studied in rats. Alangium salvifolium gave maximum extractive values with Ethanol and the Loss on Drying value, total ash value and acid-insoluble ash and water soluble ash values were within limits. The extract gave positive tests for phytosterols, triterpenes, flavonoids, carbohydrates and alkaloids. The extract was free from glycosides, saponins, tannins, proteins and amino acids. In acute toxicity studies, Alangium salviifolium root extract was found to be safe up to 3000 mg kg⁻¹, p.o. in the albino rats. The Alangium salviifolium root gave significant per cent inhibition of the maximal paw oedema and very highly significant per cent inhibition of total paw oedema during 6 h. This study revealed that Alangium salviifolium root has good anti-inflammatory actions when compared with Diclofenac sodium.
Combating antibiotic resistance requires discovery of novel antimicrobials effective against resistant bacteria. Herein, we present for the first time, pGLO plasmid transformed Escherichia coli HB 101 K 12 as novel model for screening of nanomaterial-based antimicrobial agents against b-lactamase resistance. E. coli HB 101 was transformed by pGLO plasmid in the presence of calcium chloride (50 mM; pH 6.1) aided by heat shock (0-42-0°C). The transformed bacteria were grown on Luria-Bertani agar containing ampicillin (amp) and arabinose (ara). The transformed culture was able to grow in the presence of ampicillin and also exhibited fluorescence under UV light. Both untransformed and transformed bacteria were used for screening citrate-mediated nanosilver (CNS), aloin-mediated nanosilver (ANS), 11-a-ketoboswellic acid (AKBA)-mediated nanosilver (BNS); nanozinc oxide, nanomanganese oxide (NMO) and phytochemicals such as aloin and AKBA. Minimum inhibitory concentrations (MIC) were obtained by microplate method using q-iodo nitro tetrazolium indicator. All the compounds were effective against transformed bacteria except NMO and AKBA. Transformed bacteria exhibited reverse cross resistance against aloin. ANS showed the highest antibacterial activity with a MIC of 0.32 ppm followed by BNS (10.32 ppm), CNS (20.64 ppm) and NZO (34.83 ppm). Thus, pGLO plasmid can be used to induce resistance against b-lactam antibiotics and the model can be used for rapid screening of new antibacterial agents effective against resistant bacteria.
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