A Novel Schiff base as ON donor was synthesized by green methodology by condensation of 2-hydroxyacetophenone with Furfurylamine via microwave assisted reaction in fruit juice medium. Thus an efficient, green, cost-effective and eco-friendly method has been developed, using some common fruit juices as current approach of synthesizing Schiff base which has given a new direction in the field of green chemistry. This method was also compared with conventional method and grinding method for determination of production efficiency and production economic. The Schiff base was characterized based on the results obtained from CHN analysis, NMR, FTIR, LCMS and electronic spectral data. The geometry of the Schiff base was evaluated using molecular calculation with Argus lab software. The Schiff base ligand was tested for antibacterial activity against Gram positive bacteria Staphylococcus aureus and Bacillus subtilis and Gram negative bacteria Escherichia coli and Pseudomonas aeruginosa, and antifungal activity against Fusarium oxysporum and Fusarium recini, where the ligand showed good biological activity.
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