Etched Fiber Bragg Grating Sensor for Quantification of DNA

Kavitha, B.; Radhika, N.; Gorthi, Sai Siva; Asokan, S.

doi:10.1109/jsen.2020.3020943

Cited by 18 publications

(6 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Single strand (ssDNA) of 20 nucleotides are immobilised on the surface of an eFBG sensor using glutaraldehyde followed by in situ detection of complementary target oligonucleotide. rGO functionalised eFBG sensor (figure 9) has been used for the detection and quantification of 50 base long oligonucleotide (dsDNA) [172]. The authors have demonstrated a limit of detection (LOD) of 261.87 pg µl −1 with a dynamic range from 1 ng µl −1 upto 50 ng µl −1 with excellent stability and repeatability.…”

Section: Oligonucleotides (Dna)mentioning

confidence: 99%

Fiber grating sensors and their recent applications in biomedical domain

Kavitha

Pant

Sood

et al. 2023

J. Opt.

Self Cite

View full text Add to dashboard Cite

AbstractSensors play an important role in measuring various physio chemical and biological parameters. Biomedical applications of sensors include early level diagnosis of diseases, treatment technique enhancement and also monitoring the effect of medical techniques using suitable biomedical devices. The sensors which are deemed suitable for biomedical applications need to be fast, accurate, flexible, small, and most importantly, biocompatible. The inherent advantages of fiber optic sensors, such as small foot print, electrical passiveness, multiplexing capability and fast response make them the most preferred for biomedical sensing applications. Fiber optics sensors are generally used in the measurement of parameters such as temperature, strain, pressure, displacement, angle, and force. and find applications in diverse regimes like structural health monitoring, shape sensing, seismic sensing; in the bio medical domain, they have been deployed in gait analysis, pulse rate monitoring, body joint angle measurements, acquisition of respiratory parameters, cardiovascular parameters and many more. Despite being a topic of significant interest in biomedical applications, the adoptablility of optical sensors in clinical practice is not very encouraging. Hence, there is a need to address the reasons for the same, and the present review aims to highlight some critical areas. The present review paper primarily discusses the optical fibre grating techniques: their fabrication methods, the applications of these sensors in biophysical and biomechanical measurements, bio proteins and biomarker detection in body fluids. The review also discusses the bottlenecks in the clinical application of these sensors. The comparison of the performance of the optical fibre sensors with other sensing techniques is also discussed in this review paper.

show abstract

Section: Oligonucleotides (Dna)mentioning

confidence: 99%

Fiber grating sensors and their recent applications in biomedical domain

Kavitha

Pant

Sood

et al. 2023

J. Opt.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Furthermore, the reported sensor shows excellent sensitivity without any additional metallic depositions on the fiber surface, which makes the sensor cost effective compared to other available devices. In 2020, a similar etching technique was utilized on FBG by Kavitha et al to improve the LOD by depositing the reduced graphene oxide (rGO) on the etched portion for the detection and quantification of dsDNA [ 47 ]. In that work, authors reduced the diameter up to 10.1 µm, and immobilized rGO on top of it to reach an overall diameter of 13.92 µm.…”

Section: Fiber Optic Biosensorsmentioning

confidence: 99%

Optical Fiber, Nanomaterial, and THz-Metasurface-Mediated Nano-Biosensors: A Review

et al. 2022

View full text Add to dashboard Cite

The increasing use of nanomaterials and scalable, high-yield nanofabrication process are revolutionizing the development of novel biosensors. Over the past decades, researches on nanotechnology-mediated biosensing have been on the forefront due to their potential application in healthcare, pharmaceutical, cell diagnosis, drug delivery, and water and air quality monitoring. The advancement of nanoscale science relies on a better understanding of theory, manufacturing and fabrication practices, and the application specific methods. The topology and tunable properties of nanoparticles, a part of nanoscale science, can be changed by different manufacturing processes, which separate them from their bulk counterparts. In the recent past, different nanostructures, such as nanosphere, nanorods, nanofiber, core–shell nanoparticles, nanotubes, and thin films, have been exploited to enhance the detectability of labelled or label-free biological molecules with a high accuracy. Furthermore, these engineered-materials-associated transducing devices, e.g., optical waveguides and metasurface-based scattering media, widened the horizon of biosensors over a broad wavelength range from deep-ultraviolet to far-infrared. This review provides a comprehensive overview of the major scientific achievements in nano-biosensors based on optical fiber, nanomaterials and terahertz-domain metasurface-based refractometric, labelled and label-free nano-biosensors.

show abstract

“…One sensor is dropped with NH 4 OH: H 2 O 2 : H 2 O [1:1:5], followed by rGO dip (allowed to dry ≈4 h at room temperature) and finally washed in deionized (DI) water. [ 19 ] The resultant sensor is referred to as the rGO sensor. The second and third sensors are coated with PVA and PVA–rGO nanofibers, respectively, by electrospinning.…”

Section: Fabrication Of Rgo Pva and Pva–rgo Efbg Sensorsmentioning

confidence: 99%

“…After Iadicicco et al demonstrated the dependence of refractive index (RI) sensitivity on cladding diameter, [12] the applications of etched fiber Bragg grating (eFBG) sensors as RI sensor, pressure sensor, fuel-level sensor, temperature sensor, gas sensor, and biosensor [13][14][15][16][17][18][19][20] are well documented. Even though these sensors have been a research topic for more than 10 years, translating from an idea to a product has not happened due to nonreproducible results, primarily from the coating's nonuniformity due to their microscale diameter.…”

mentioning

confidence: 99%

Enhanced Optical Sensitivity of Polyvinyl Alcohol–Reduced Graphene Oxide Electrospun Nanofiber Coated Etched Fiber Bragg Grating Sensor for Detection of Myoglobin a Cardiac Biomarker

Srinivasan

Raghavan

Shorie

et al. 2021

Advanced Photonics Research

Self Cite

View full text Add to dashboard Cite

Cardiovascular disease (CVD) can be diagnosed in the early stages through primary health care screening of cardiac biomarkers such as myoglobin, creatine kinase (CK), troponin I, and T. Existing CVD diagnostic methods generally rely on expensive classical assays such as immunoproteins-based enzymelinked immunosorbent assay or paperbased lateral flow assays based on centralized laboratories with test results available only after several hours. The assays are also focussed on the diagnosis and postdisease management with the dynamic ranges optimized around the higher concentration ranges, rendering these detection routes useless in the early phase disease screening. Real-time, economically viable, pointof-care test kits at normal temperature and pressure (NTP) for cardiac biomarkers will help screen in remote locations and developing countries to reduce myocardial infarction (MI) risks. Many research groups working toward this goal have developed sensors/techniques based on strain using cantilevers [1] ; electrochemical (conductance/resistance) [2,3] ; optical methods including fluorescence, [4] colorimetric, [5] UV-Vis, [6] and photonic crystals. [7] Molecularly imprinted polymers (MIPs) are also finding applications with enhanced performance. [8,9] Another technique gaining popularity is polymer nanofibers embedded with nanomaterials adopted in electrochemical and

show abstract

Etched Fiber Bragg Grating Sensor for Quantification of DNA

Cited by 18 publications

References 23 publications

Fiber grating sensors and their recent applications in biomedical domain

Fiber grating sensors and their recent applications in biomedical domain

Optical Fiber, Nanomaterial, and THz-Metasurface-Mediated Nano-Biosensors: A Review

Enhanced Optical Sensitivity of Polyvinyl Alcohol–Reduced Graphene Oxide Electrospun Nanofiber Coated Etched Fiber Bragg Grating Sensor for Detection of Myoglobin a Cardiac Biomarker

Contact Info

Product

Resources

About