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Abstract. Polyacrylamide gel beads with monomer concentrations ranging from 5 to 30% and with constant degree of cross-linking (5 % ) were prepared. Dried beads were swollen in buffered HLAD/NAD + solutions and placed in a water-immiscible organic solution of substrates. Increased enzymatic activity was observed in beads with higher polymer density. Evidence is given that catalyst in the high-density polymer is concentrated in the outer part of the beads, but is homogeneously distributed in low-density polymers. This was clearly visualised by high-resolution NMR imaging on gel beads impregnated with Gd-DTPA-labeled HLAD. Furthermore, reaction rates were higher for larger beads.

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Nuclear magnetic resonance (NMR) imaging of the central nervous system (CNS) is by far the most sensitive technique for the visualization of multiple sclerosis (MS) lesions. At this moment there is no clear correlation between NMR characteristics and neuropathological data. In this study, in vivo and in vitro high resolution NMR imaging was optimized in order to investigate the NMR characteristics of lesions in an animal model for MS. These characteristics will be correlated with the specific neuropathologic features of the lesions.

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