Proton relaxation enhancement by means of serum albumin and poly-l-lysine labeled with DTPA-Gd3+: Relaxivities as a function of molecular weight and conjugation efficiency

Spanoghe, M.; Lanens, D.; Dommisse, Roger; Linden, Annemie Van der; Alderweireldt, F. C.

doi:10.1016/0730-725x(92)90445-6

Cited by 67 publications

(60 citation statements)

References 16 publications

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“…The r1 and r2 values of the Gd-DTPA-SP are similar to those reported for several Gd-DTPA-based macromolecules, the improved relaxivity resulting from an increase in the rotational correlation time ( R ) of the metal chelate when bound to the macromolecule, compared with free metal chelate (15,16). The low relaxivities of Dy-DTPA are due to the very short electron spin relaxation time ( S ) of the Dy ion (17).…”

Section: Discussionsupporting

confidence: 70%

Investigation of lanthanide-based starch particles as a model system for liver contrast agents

Fossheim¹,

Kellar²,

Månsson³

et al. 1999

J. Magn. Reson. Imaging

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Section: Discussionsupporting

confidence: 70%

Investigation of lanthanide-based starch particles as a model system for liver contrast agents

Fossheim¹,

Kellar²,

Månsson³

et al. 1999

J. Magn. Reson. Imaging

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“…It is widely known that relaxivities of gadolinium agents depend on not only theˆeld strength, 6,8,12 but also the temperature 13 and type and content of macromolecules. 11,14,15 To clarify theˆeld-strength dependence of the contrast enhancement, other conditions should be as identical as possible between scanners, as were the conditions we used.…”

Section: Discussionmentioning

confidence: 99%

Enhancement Effects and Relaxivities of Gadolinium-DTPA at 1.5 versus 3 Tesla: A Phantom Study

Sasaki

Shibata

Kanbara

et al. 2005

MRMS

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Purpose: To investigate the diŠerence in enhancement eŠects and relaxivities of the gadolinium chelate at 1.5 and 3 Tesla (T) and to elucidate the contribution of the high magneticˆeld to contrast enhancement in spin-echo (SE) and gradient-echo (GRE) images.Methods: Phantoms containing water with or without gadopentetate dimeglumine (Gd-DTPA) at diŠerent concentrations were scanned using 1.5T and 3T MRI scanners of the same manufacturer and under the same temperature conditions and scanning parameters. Relaxivities of gadolinium, R 1 and R 2 , were estimated from serial T 1 and T 2 values of the phantoms using linear regression. Contrast enhancement ratios in SE and GRE T 1 -weighted images were compared at 1.5 and 3T.Results: The R 1 and R 2 of Gd-DTPA at 1.5 and 3T were 4.79 and 5.14, and 4.50 and 5.09, respectively. Although the relaxivities at 3T were slightly lower than those at 1.5T, the contrast enhancement ratio improved in both SE and GRE images as a result of T 1 prolongation of the water at 3T.Conclusion: The decrease in relaxivities of the Gd-DTPA at 3T appears to be so small that T 1 prolongation of the water improves contrast enhancement, suggesting a potential clinical advantage in administration of Gd-DTPA at highˆeld strength.

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“…The spin rotation (SR) contribution is a magnetic-field-independent mechanism which may be approximated with Equation (11) in which dg 2 L S i dg 2 Li , which refers to the deviations from the free-electron value of…”

Section: Appendix 17mentioning

confidence: 99%

Inulin as a Carrier for Contrast Agents in Magnetic Resonance Imaging

et al. 2001

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Magnetic resonance angiography (MRA) has put forth an impetus for the development of macromolecular GdIII complexes that have a prolonged lifetime in the vascular system. Herein, we report the synthesis and GdIII complexation of a new sugar conjugate based on inulin and the DO3A ligand (DO3A = 1,4,7,10-tetraazacyclododecan-1,4,7-triacetic acid). Two API-DO3ASQ conjugates (API = O-(aminopropyl)inulin, SQ = squaric acid = 3,4-dihydroxy-3-cyclobutene-1,2-dione) with different degrees of substitution (ds = 0.7 and ds = 1.5) were prepared from API by using the diethyl ester of squaric acid as a linking agent for the DO3A chelate. The efficacies of the resulting GdIII compounds were evaluated by investigation of their water 1H longitudinal-relaxation-rate enhancements at variable field (NMRD). A dramatic increase in relaxivity was observed in the more highly substituted conjugate (ds = 1.5); this prompted us to do a variable-temperature (17)O study in order to further characterize the relaxation parameters involved in this system. [Gd(API-DO3ASQ)] shows promising properties for application as a contrast agent for MRI.

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Proton relaxation enhancement by means of serum albumin and poly-l-lysine labeled with DTPA-Gd3+: Relaxivities as a function of molecular weight and conjugation efficiency

Cited by 67 publications

References 16 publications

Investigation of lanthanide-based starch particles as a model system for liver contrast agents

Investigation of lanthanide-based starch particles as a model system for liver contrast agents

Enhancement Effects and Relaxivities of Gadolinium-DTPA at 1.5 versus 3 Tesla: A Phantom Study

Inulin as a Carrier for Contrast Agents in Magnetic Resonance Imaging

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