Infection is a major cause of morbidity and mortality in bone marrow transplant recipients and in patients with hematological malignancies. The source of infection is almost always endogenous flora or the hospital environment. The present study evaluated bone marrow transplant recipients and patients with hematological malignancies colonized and/or infected with filamentous fungi. During 1 year, environmental air samples were also taken from the bone marrow transplant unit by a modification of gravity air-setting plate (GASP) methodology. Fusarium spp. were the most prevalent genus in the fall and Cladosporium spp. in the winter. Clinically isolated strains grew better at 37 degrees C than environmental strains. According to NCCLS M-38P methods, environmental Aspergillus strains showed higher MICs to miconazol and itraconazol, and clinical Fusarium strains were less susceptible to fluconazole.
Life cycle assessment (LCA) is an important technique to measure environmental impacts of products and processes and its application to diagnose and optimize whole-buildings’ environmental performance has increased in the past years. However, LCA results carry uncertainties which may limit their utility as environmental decision-making support. Since normative choices are unavoidable within whole-building LCA (wbLCA) modelling, it becomes important to analyse their inherent uncertainty. Recent literature indicates that different material wastage values, lifetime choices and end of life scenarios are the main uncertainties drivers on wbLCA. To understand how these choices influence wbLCA results, we conducted a scenario analysis, to estimate the effects that parameters and input choices produce on final results by describing possible future situations. Cumulative Energy Demand (CED) and CML 2001 v.2.05 methods were selected for calculating embodied energy and global warming potential in SimaPro 7.3. Our results indicate that wbLCA outcomes vary greatly with different alternatives for normative choices, and a scenario uncertainty analysis is necessary to understand all implications of its results.
O artigo estuda o papel do PMN na defesa do organismo nas infecções por Candida, e o significado da permanência da Candida viva no interior dos neutrófilos.
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