Background and aim The treatment of diabetic ulcers is difficult because of defective blood vessels and frequent co-occurrence of bacterial infections. In a previous study, we found a water fraction of Merremia mammosa (Lour.) (Mm(Lour.)) had beneficial effects on wound healing in diabetic rats. This study aimed to evaluate the influence of different gelling agents added to Mm(Lour.) water fraction gel on wound healing treatment in diabetic rats. Experimental procedure Diabetic Wistar rats were divided into the following five groups: 1. positive control (Neomycin Sulfate 0.5% and Placenta Extract 10%), 2. negative control (distilled water), and 10% water fraction of Mm(Lour.) extract in 3. HPMC, 4. Carbopol, and 5. CMC Na gelling agents. The wound was made by the Morton method and treatment applied every other day for 25 days, then the wound healing process was observed. Data were observed and analysed using appropriate statistic tools. Results Histopathology observation, VEGF expression and hydroxyproline levels showed a significant acceleration of wound healing in all treatment groups compared to the negative control group. This study showed all of Mm(Lour.) gel formulations could restore the delayed healing process on wound in diabetic rats and were equally effective in accelerating wound healing. CMC Na was the most preferable because it did not irritate. Conclusion The results suggest that Mm(Lour.) water fraction in CMC Na gelling agent provided an option to be developed as a topical drug on diabetic wound healing treatment, showed by enhancement of collagen synthesis and angiogenesis.
Analysis performance of uranium plutonium carbide (UC-PuC) as fuel in gas cooled fast reactor (GFR) with addition of protactinium as a burnable poisons has been done. Neutronic analysis in this research was carried out using the SRAC code from JAERI with a nuclear library based on JENDL 4.0. The calculation is carried out by two steps, the first step is the PIJ calculation which calculates the fuel cell and the second step is the CITATION calculation which calculates the various configurations of the reactor core. The first calculation determines the k-eff value in a homogeneous core configuration. The results obtained show that the percentage of 10% is the sloping result with a k-eff value of 1%. The second calculation determines the k-eff value in the heterogeneous core configuration. The results obtained indicate that the fuel variation 8% -10% -12% is the most critical percentage with a peak power density value of less than 100 Watt/cc. Furthermore, the addition of protactinium with a variation of 0% to 5%. At a protactinium 4% percentage and 63% fuel fraction, the excess reactivity value is 1.02% or close to 1% which indicates that the reactor is in a critical condition.
Adanya wabah COVID-19 yang melanda seluruh dunia, banyak sektor perekonomian yang menurun dan mengalami banyak kerugian, bahkan di Indonesia sendiri masih berusaha keras untuk mengembalikan perekonomian didalam negeri dengan pemberlakuan PPKM di seluruh wilayah pulau jawa dan bali. Salah satu UMKM yang terdampak ialah Peternakan miliki salah seorang peternak di Desa Negla kabupaten Brebes jawa tengah, dimana setelah pemberlakuan aturan pemerintah kini usahanya menurun dari jumlah pesanan ikan lele tidak seperti panen lele sebelumnya yang hampir setiap hari ada pesanan bahkan kadang mengalami kekurangan hasil panenya, Oleh karena itu dibutuhkan edukasi dan pelatihan mengenai peningkatan manajemen pengelolaan usaha melalui pemanfaatan teknologi berbasis digital. Guna sebagai upaya penanganan permasalahan yang sedang terjadi di usaha peternakan lele milik Bapak Toha.
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