Gel formulations of Merremia mammosa (Lour.) accelerated wound healing of the wound in diabetic rats

Marchianti, Ancah Caesarina Novi; Sakinah, Elly Nurus; Elfiah, Ulfa; Putri, Nurin Kamila Suwandi; Wahyuliswari, Deuxy Ilma; Maulana, M. Rizqi; Ulfa, Evi Umayah

doi:10.1016/j.jtcme.2019.12.002

Cited by 19 publications

(13 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1 Hyperglycemia can interfere with the regulation of cellular functions, such as defective T-cell immunity, abnormalities in leukocyte chemotaxis, phagocytosis, bactericides, and fibroblast and epidermal cell dysfunction. 2 The present study results showed that Lagerstroemia speciosa and aloe vera extracts gel's application affected the wound healing process in the palate of hyperglycemic rats compared to the untreated group. This result was proofed from the significant differences in the FGF-2 expression level in the Lagerstroemia speciosa and aloe vera extracts gel group on the fourteenth observation day (p-value<0.05).…”

Section: Discussionmentioning

confidence: 46%

“…The uncontrolled hyperglycemic condition in diabetes can reduce inflammatory processes, angiogenesis, and collagen synthesis in wound healing. 2 Hyperglycemic condition can reduce the function of red blood cells that carry nutrients to the tissues, as well as reduce the efficiency of leukocytes in fighting infection. Narrowing of blood vessels can cause decreased blood flow and oxygen to the wound, so that without adequate nutrition and oxygen, wound healing will occur slowly.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Expression of fibroblast growth factor-2 after application of the Queen's crepe-myrtle leaf (Lagerstroemia speciosa) and aloe vera extract gel in the wound healing process of hyperglycemic

et al. 2021

View full text Add to dashboard Cite

Introduction: Fibroblast Growth Factor-2 (FGF-2) have a role in stimulating the proliferation and migration of various types of cells in the wound healing process. Hyperglycemic conditions can disrupt the wound healing process. Lagerstroemia speciosa are known to have antyphyerglycemic and antioxidant effects. Aloe vera is a plant that has been used for long time in topical treatment of wounds.This study was aimed to analyse the FGF-2 expressions on the wound healing process of subjects with hyperglycemia after application of Queen's crepe-myrtle leaf (Lagerstroemia speciosa) and aloe vera extracts gel. Methods: A pure experimental study was conducted with simple random sampling. The sample was 27 experimental animals (CI 95%; power test 80%) of Sprague Dawley rat induced to have a hyperglycemic state using alloxan and had their palate injured. The immunohistochemical examination was performed to assess FGF-2 expression level. Samples were divided into three groups with a simple random sampling technique: nine of the rats received the Lagerstroemia speciosa extract gel application; nine rats received the aloe vera extract gel application on the injured palate; another nine rats in the control group. Examination of the FGF-2 expression level was performed on the third, seventh, and fourteenth observation days. Results: Overall, the control group had a significant difference with the Lagerstroemia speciosa and aloe vera extract gel group (p-value<0.05), however, the Lagerstroemia speciosa group did not have any significant difference with the aloe vera group (0.123>0.05). Conclusion: There was no difference in the amount of FGF-2 expressions on the wound healing process of the injured palatal tissue of Sprague-Dawley rats with hyperglycemic after application of the Lagerstroemia speciosa and aloe vera extract gel.

show abstract

Section: Discussionmentioning

confidence: 46%

Section: Introductionmentioning

confidence: 99%

Expression of fibroblast growth factor-2 after application of the Queen's crepe-myrtle leaf (Lagerstroemia speciosa) and aloe vera extract gel in the wound healing process of hyperglycemic

et al. 2021

View full text Add to dashboard Cite

show abstract

“…In Indonesia, the leaf and whole plant of M. mammosa, prepared by infusion and maceration, respectively, have been reported to be beneficial in the treatment and management of diabetes [56] and diabetic ulcers [57]. The leaves of M. peltata prepared by maceration have been employed in the treatment of different forms of cancer, diarrhea, abdominal pain, cough, sore eyes, wounds, and inflammation [58].…”

Section: Ethnomedicinal Uses Of Merremia Speciesmentioning

confidence: 99%

“…In another study, Marchianti et al [57] investigated the wound-healing potency of 1.5% M. mammosa plant gel formulations (incorporation of hydroxypropylmethylcellulose (HPMC), Carbopol, or sodium carboxymethylcellulose (Na CMC) into 10% water fraction of the plant's ethanol extract) in diabetic Wistar rats by percentage wound size reduction, vascular endothelial growth factor expression, hydroxyproline levels, and histopathology assessments. Diabetes was induced by streptozotocin (40 mg kg −1 BW, IP), while the wound was excised using the Morton method.…”

Section: Wound Healing Propertymentioning

confidence: 99%

Research Progression of the Genus Merremia: A Comprehensive Review on the Nutritional Value, Ethnomedicinal Uses, Phytochemistry, Pharmacology, and Toxicity

Olatunji

Adetunji

Olisah

et al. 2021

Plants

View full text Add to dashboard Cite

The genus Merremia Dennst. ex Endl. (Convolvulaceae) is a rich source of structurally diverse phytochemicals with therapeutic relevance. This review presents the first comprehensive, up-to-date information and research progression on the nutritional value, ethnomedicinal uses, phytochemistry, pharmacological activities, and toxicity of the genus Merremia. Using the key search term “Merremia”, relevant documents and information were retrieved from electronic databases. Relevant documents were uploaded in RStudio with installed bibliometric software packages and used for data retrieval, tabulation, and network visualization. Bibliometric analysis revealed that ca. 55% of the studies related to Merremia were published in the last decade, which can be grouped into four thematic areas: (i) drug formulation, (ii) taxonomy, (iii) chemical analysis, and (iv) treatment of diseases. Ethnomedicinal uses, phytochemistry, and biological activities studies showed that species in the genus are promising medicinal plants with various pharmaceutical potentials. However, clinical studies to validate the efficacy of the reported bioactivities and the mechanisms underlying the various activities are lacking and should constitute a future research focus. Additionally, reports on the nutritional and antinutritional constituents of Merremia species revealed that the species meet high nutritional quality criteria for animals and are therefore suitable for inclusion in livestock diets. The few available investigations on toxicity indicated that most Merremia species are safe for human and animal use but not with prolonged chronic administration.

show abstract

“…Pemberian obat Merremia mammosa (Lour.) secara topikal pada pengobatan penyembuhan ulkus diabetikum, ditunjukkan dengan peningkatan sintesis kolagen dan angiogenesis (Marchianti et al, 2020).…”

Section: J Daun Bidara Upas (Merremia Mammosa Lour)unclassified

Therapeutic Effects of Medicinal Plants on Diabetic Foot Ulcers: A Systematic Review

Refiani

Maliza

Fitri

et al. 2021

AMS

View full text Add to dashboard Cite

Diabetic Foot Pain and Ulcers is one of the complications diseases caused by Diabetes Mellitus (DM). Based on data from the Ministry of Health in 2014, diabetic foot ulcers in Indonesia 54%. Diabetic foot ulcer disease can cause infection and tissue death. Treatment of diabetic foot ulcers has been treated with ointments or gels containing antimicrobials, biomaterials, and active compounds, accelerating the wound healing process. The active compounds from medicinal plants that play a role in the treatment of diabetic foot ulcers have been widely reported. The purpose of writing this article is to look at the therapeutic effects of active compounds that play a role in wound healing. In this systematic review, we searched the PubMed, Science Direct, and Google Scholar databases to identify primer articles that were published from 2010 to 2020. Ten studies were selected and published between 2015-2020. Furthermore, the plant species used for the treatment of diabetic foot ulcers contain active phenolic, gallic acid, flavonoids, gallic acid, flavonoids, and tannins compounds that play a role in the acceleration of the healing process of diabetic foot ulcers. Keywords: Diabetes mellitus, diabetic foot ulcers, the active compound, medicinal plants

show abstract

Gel formulations of Merremia mammosa (Lour.) accelerated wound healing of the wound in diabetic rats

Cited by 19 publications

References 32 publications

Expression of fibroblast growth factor-2 after application of the Queen's crepe-myrtle leaf (Lagerstroemia speciosa) and aloe vera extract gel in the wound healing process of hyperglycemic

Expression of fibroblast growth factor-2 after application of the Queen's crepe-myrtle leaf (Lagerstroemia speciosa) and aloe vera extract gel in the wound healing process of hyperglycemic

Research Progression of the Genus Merremia: A Comprehensive Review on the Nutritional Value, Ethnomedicinal Uses, Phytochemistry, Pharmacology, and Toxicity

Therapeutic Effects of Medicinal Plants on Diabetic Foot Ulcers: A Systematic Review

Contact Info

Product

Resources

About