Starting from erythritol, enzyme catalyzed construction of C4 chiral building blocks is described. The four diastereomeric protected tetroses are available from this single compound. Also an approach to L-and D-hexosederivatives is presented.
SummaryThe enantioseparation of some 2,2-dialkyl-4-alkoxycarbonyl-l,3-dioxolane derivatives, which are important intermediates in the total synthesis of a number of biologically active compounds, was studied by means of capillary gas chromatography (CGC). The chromatographic results, obtained on columns coated with permethylated a-, p-and y-cyclodextrin respectively, are reported. Out of sixteen compounds, thirteen could be separated with a resolution superior to 1,2. One racemate could not be separated on any of the columns.Considerations concerning the separation mechanism are proposed.
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