Abstract. An evaluation of the effects of differently derivatized cyclodextrins and analyte geometry for a series of 2,2-dialkyl-4-alkoxycarbonyl-l,3-dioxolane derivatives on enantioselectivity has been performed. It was shown that changes in the cyclodextrin cavity size, caused by either the choice of type (a-, 0-or y-cyclodextrin) or substitution pattern, strongly affect the selectivity of the chiral separation of the substituted dioxolanes. The geometry of the analyte also appears to be very important to the selectivity. A model of the inclusion complex is proposed.
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