Synthesis and Anti-Monoaminooxidase Activity of (4-Dialkylamino-6-methylpyrimidin-2-yl)thioacetic Acid Isopropylhydrazides.-Reduction of the isopropylidenehydrazides (I) with excess sodium borohydride proceeds smoothly to afford the corresponding title isopropylhydrazides (II). All synthesized derivatives possess antimonoaminooxidase activity. The best results are obtained for the dimethylamino derivative (IIa). - (BURBULENE, M.-M.; ROCHKA, V.-S.; VAINILAVICHYUS, P.; Khim.-Farm. Zh. 33 (1999) 2, 21-23; Vil'nyusskii univ., Vil'nyus 2006, Lithuania; RU)
Synthesis and Hypolipidaemic Activity of Isopropylidenehydrazides of (4-Dialkylamino-6-methyl-2-pyrimidinylthio)acetic Acids. -The title isopropylidenehydrazides (III), easily obtained by reaction of the hydrazides (I) with acetone, possess a high hypolipidemic activity but a reduced acute toxicity compared to the hydrazides (I). -(BURBULENE, M.-M.; ROCHKA, V.-S.; VAINILAVICHYUS, P.; Khim. -Farm. Zh. 32 (1998) 1, 7-9; Inst. mater. prikl. nauk, Vil'nyusskii univ., Vil'nyus, Lithuania; RU)
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