Synthesis and hypolipidemic activity of (4-dialkylamino-6-methyl-2-pyrimidinylthio)acethydrazides

Vainilavichyus, P. I.; Burbulene, M.‐M.; Rochka, V. C. M.; Lautsyuvene, N. D. I.

doi:10.1007/bf00773091

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Experimental Chemical Part2

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1998

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“…The hypolipidemic activity of isopropylidenehydrazides lla-IIe is comparable to that of hydrazides Ia-Ie studied previously [2]. However, the replacement of the hydrazide group in la-Ie by the isopropylidenehydrazide group in IIalie led to a markedly reduced acute toxicity of the latter group.…”

Section: Experimental Pharmacological Partsupporting

confidence: 68%

“…The data of elemental analyses of compounds IIa-IIe for C, H, N, and S agree with the results of analytical calculations according to the empirical formulas. The initial hydrazides Ia-Ie were synthesized as described in [2].…”

Section: Experimental Chemical Partmentioning

confidence: 99%

“…It was reported that 2-(pyrimidinylthio)acetic acid hydrazides containing amino substituents in position 4 of the pyrimidine ring exhibited hypolipidemic activity, albeit in combination with comparatively high toxicity [ 1,2].…”

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confidence: 99%

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