NRC Publications Record / Notice d'Archives des publications de CNRC:http://nparc.cisti-icist.nrc-cnrc.gc.ca/npsi/ctrl?action=rtdoc&an=12744313&lang=en http://nparc.cisti-icist.nrc-cnrc.gc.ca/npsi/ctrl?action=rtdoc&an=12744313&lang=fr READ THESE TERMS AND CONDITIONS CAREFULLY BEFORE USING THIS WEBSITE.http://nparc.cisti-icist.nrc-cnrc.gc.ca/npsi/jsp/nparc_cp.jsp?lang=en Vous avez des questions? Nous pouvons vous aider. Pour communiquer directement avec un auteur, consultez la première page de la revue dans laquelle son article a été publié afin de trouver ses coordonnées. Si vous n'arrivez pas à les repérer, communiquez avec nous à PublicationsArchive-ArchivesPublications@nrc-cnrc.gc.ca. Questions?Contact the NRC Publications Archive team at PublicationsArchive-ArchivesPublications@nrc-cnrc.gc.ca. If you wish to email the authors directly, please see the first page of the publication for their contact information. NRC Publications Archive Archives des publications du CNRCThis publication could be one of several versions: author's original, accepted manuscript or the publisher's version. / La version de cette publication peut être l'une des suivantes : la version prépublication de l'auteur, la version acceptée du manuscrit ou la version de l'éditeur. For the publisher's version, please access the DOI link below./ Pour consulter la version de l'éditeur, utilisez le lien DOI ci-dessous.http://doi.org/10.1063/1.1608488Applied Physics Letters, 83, 13, pp. 2638Letters, 83, 13, pp. -2640Letters, 83, 13, pp. , 2003 Interfacial growth in HfO x N y gate dielectrics deposited using †"C 2 H 5 … 2 N ‡ The interface growth by oxygen diffusion has been investigated for 5 nm thick HfO x N y gate-quality dielectric films deposited on Si͑100͒ by low-pressure pulsed metalorganic chemical vapor deposition. Analysis by x-ray photoelectron spectroscopy of the films deposited using the precursor tetrakis ͑diethylamido͒ hafnium with O 2 showed that the films contained 4 at. % nitrogen. This increased to 11 at. % N when NO was used as the oxidant. Significant growth of the interface layer was observed for films exposed to air at ambient temperature and lower rates of growth were observed for vacuum annealed films and those with the higher N content. For films annealed in O 2 at temperatures in the range 600-900°C, the activation energies of the interfacial growth were 0.36 and 0.25 eV for N concentrations of 11 and 4 at. %, respectively. The results were interpreted in terms of atomic oxygen formation in the bulk and reaction at the interface. The increase in N incorporation from 4 to 11 at. % increases the crystallization temperature from between 500 and 600°C to between 600 and 700°C. Hafnium oxide has proven to be one of the most promising candidates to replace SiO 2 as the gate insulator in sub-0.1-m complementary metal oxide semiconductor ͑CMOS͒ devices due to its relatively high dielectric constant and thermodynamic stability when in direct contact with Si.1,2 However, the high oxygen diffusion rate through hafnium oxide, 3 whic...

The EST approach is an effective way of characterizing the genes expressed in cartilage. These data represent the most extensive molecular information on human fetal cartilage to date. The availability of this information will serve as a basis for further research to identify genes that are essential in cartilage development.

Transgelin-2 is known to induce actin polymerization, thereby playing a critical role in cytoskeletal reorganization leading to cell proliferation, migration/invasion, and therapeutic resistance in GBM and other malignancies. This study aims to establish Transgelin-2 as a potential therapeutic target in GBM and to demonstrate that targeting transgelin-2 by pharmacological inhibitors would provide a novel strategy for therapeutic intervention. Materials/Methods: RNAi-mediated TAGLN-2 knockdown (KD) approach was employed to assess the functions of Transgelin-2 in PDX GBM cell lines. A series of in-vitro functional assays was performed to assess the role of Transgelin-2 in these cell lines. Structure-based computational screening approach was employed to identify small-molecule inhibitors of Transgelin-2. Subsequently, the efficacy of these inhibitors to inhibit Transgelin-2-mediated cell proliferation/survival, invasion, and colony-formation was evaluated. Results: RNAi-mediated silencing Transgelin-2 significantly inhibited proliferation, survival, clonal expansion, and invasion of GBM 08-387 and 3359 PDX cell lines in vitro. In-silico virtual screenings identified potential Transgelin-2 binding candidates and were predicted to be able to permeate blood-brain barrier. In vitro binding study confirmed that these compounds inhibit the Transgelin-2-dependent actin-polymerization, and significantly compromised the proliferation invasion of GBM cells as assessed by proliferation, survival, clonal expansion, and invasion of GBM 08-387 and 3359 PDX cell lines. Furthermore, it is noteworthy that it is more likely that other pro-invasion pathways like MMP2/9-pathways may compensate for loss of function of transgelin-2 and needs to be addressed as well. MMP2 and MMP9 are important determinants in cell migration/invasion and found to be differentially upregulated in human GBM tissue compared to normal brain tissue Therefore, a combinatorial approach including Transgelin-2 inhibitor and MMP inhibitor may provide additive/synergistic outcome. Conclusion: Our data suggest that Transgelin-2 may serve as a potential therapeutically vulnerable target in GBM. Importantly, select small molecule inhibitors of Transgelin-2 that inhibit cell proliferation, invasion and therapeutic resistance may have potential preclinical trials.

use in situ simulation (18%) and hold a simulation boot camp (41%). Most centres required an academic project, most commonly a quality assurance project (53%) and/or a critical appraisal of the literature (59%). Publication or national conference presentations were required by 12% of programs. Competency based assessments use simulation (88%) and direct observations (53%). Only 24% of programs have a transition to practice curriculum. All programs maintain strong connections to family medicine. Conclusion: This study demonstrates diverse structures of CCFP(EM) programs across Canada. Programs are similar regarding the provision of ultrasound, simulation and protected teaching time. Variation exists in administrative structure and financial resources of each program, academic project requirements, and how programs perform competency based assessments. Keywords: emergency medicine program, certification in the College of Family Physicians -emergency medicine, survey LO41 Competency-based learning of pediatric musculoskeletal radiographs

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