Purpose To evaluate the efficacy of intravitreal injections of bevacizumab in exudative ARMD.
Methods Retrospective study including naive patients suffering from exudative ARMD whatever the type of neovascularisation. All the participants were treated with three monthly 1.25 mg intravitreal injections of bevacizumab.The primary objective was far and near visual acuity (VA) 1, 3 and 6 months after the third injection. The secondary objective was the residual activity of neovascularisation assessed with fluorescein and ICG angiography and retinal thickness evaluated with OCT3.
Results 71 eyes of 66 patients were included. Neovascularisation was occult, visible or combined in 65%, 20% and 15% of the cases, respectively. A statistically significant improvement between pre and post‐injection VA (LogMAR) was observed one month after the third injection, 0.88±0.57 and 0.77±0.60, respectively, p=0.001). An active neovascularisation was still present at that time in 57.7% of the eyes and 34% at 6 months needing further bevacizumab injections (3.85±0.96 per eye). VA was similar at 1, 3 and 6 months (F71,2=1,54 ; p=0,46). A complication occurred in 3 eyes.
Conclusion Three bevacizumab intravitreal injections led to a significant VA improvement. However, more than half of the eyes had an active neovascularisation after these 3 injections.
Purpose To assess the changes of the irio corneal angle configuration and anterior chamber depth with anterior segment optical coherence tomography (AS OCT) after phacoemulsification.
Methods Prospective study including consecutive patients operated on age related cataract with phacoemulsification and intraocular lens implantation. An AS OCT was performed before and one month after cataract surgery on the horizontal meridian. The primary objective was to assess the changes of AC depth, iridocorneal angle, angle opening distance at 500 and 750 µm and trabeculum iris space area at 500 and 750 µm. The secondary objective was to evaluate intra ocular pressure (IOP) changes.
Results Thirty five eyes of 35 patients were included. Mean age was 72 ± 9 years. Anterior chamber depth increased from 2.62 ± 0.39 µm to 3.66 ± 0.21 µm after cataract removal Nasal AOD 500 and 750 increased by 75 and 73%, nasal TISA 500 and 750 by 69 and 65%, and nasal angle by 52%, respectively, p<0.01. Temporal AOD 500 and 750 increased by 70 and 71%, temporal TISA 500 and 750 by 55 and 64% , and temporal angle by 42%, respectively, p<0.01. A statistically significant but weak correlation was found for AC depth change and axial length, p=0.004, r2=0.22, but not for AC depth change and age and preoperative spherical equivalent, p= 0.52 and p=0.38, respectively. The pre and post operative IOPs were 16.7 ± 3.7 mm Hg and 14.0 ± 2.7 mm, respectively, p=0.0015.
Conclusion Cataract extraction leads to important changes of anterior segment configuration evaluated with AS OCT. In our series, all measured parameters showed an opening of the IC angle with wide variation among patients.
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