Objectives:The goal of this study was to characterize Suvarna Bhasma Parada Marit by using the Ayurvedic test parameters, physico-chemical tests, and various instrumentation techniques.Methods:Suvarna Bhasma, an Ayurvedic formulation manufactured as per Bharat Bhaishajya Ratnakar 5/8357 (BBR), has been studied using various instrumentation techniques: X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDAX), laser particle size distribution (PSD) analysis, fourier transform infrared spectroscopy (FT-IR), and atomic absorption spectroscopy (AAS), and physico-chemical parameters, such as the loss on drying (LOD), loss on ignition (LOI), and acid insoluble Ash (AIA) were determined. In addition, Ayurvedic tests, such as Rekhapurnatva (enterable in the furrows of the fingers), Varitaratwa (floatable over water), Nirdhoomta (smokeless), Dantagre Kach-Kach (gritty particle feeling between the teeth), were performed.Results:The XRD study showed Suvarna Bhasma to be crystalline in nature and to contain more than 98% gold. The mean size of the gold crystallites was less than 10 microns, and the morphology was globular and irregular. Suvarna Bhasma contains gold as its single and major element, with EDAX and FT-IR spectra showing that it is more than 98% pure gold. The moisture content (LOD) is less than 0.5%, the LOI is less than 2%, and the AIA is not less than 95%. The Ayurvedic tests, as specified above, helped to confirm the quality of Suvarna bhasma prepared as per the text reference (BBR).Conclusion:This chemical characterization of Suvarna Bhasma performed in this study by using modern instrumentation techniques will be helpful in understanding its pharmacological actions and will help in establishing quality protocols and specifications to substantiate the safety, efficacy & quality of Suvarna Bhasma.
Context:Amlapitta Mishran suspension is a poly herbal ayurvedic formulation, which has been traditionally used for acidity and gastric ulcers.Aim:The aim of this study is to evaluate the antiulcer activity of Amlapitta Mishran on non-steroidal anti-inflammatory drugs (NSAID's) -induced ulcers in the rat model.Subjects and Methods:The antiulcer activity of Amlapitta Mishran was investigated on indomethacin (100 mg/kg) NSAID's induced ulcers in rats. Effect of two different doses of Amlapitta Mishran was studied by calculating the total number of ulcers, ulcer index and percentage inhibition.Statistical Analysis Used:Data was analyzed by the Student's t-test (P < 0.05).Results:Amlapitta Mishran treated rats have shown significant (P < 0.0001) decrease in the total number of ulcers and ulcer index and significant increase in % inhibition of ulcers as compared with positive control group.Conclusion:The results indicate that Amlapitta Mishran has showed a dose dependent antiulcer activity in experimental animals and confirms ayurvedic use of Amlapitta Mishran in gastric ulcers.
Purpose:Sheetaprabha tablets, Ayurvedic proprietary medicine, contain Sweta Parpati & Hajrul hahood bhasma as active ingredients. Sweta parpati is mainly indicated in mootravaha srotovikara & hajrul hahood bhasma is having mootrala and ashmari bhedana actions. A survey of the literature showed that no pharmacology study was made on the sweta parpati and sheetaprabha tablets. In the present study we investigated the effect of Sheetaprabha tablets in ethylene glycol induced urolithiasis in rats.Method:Urolithiasis was induced in male wistar rats by adding ethylene glycol (0.75%) in drinking water. Protective (130mg/kg & 260mg/kg) and curative effect (130mg/kg & 260mg/kg) of Sheetaprabha was studied in experimental animal models.Result:Ethylene glycol induced urolithiatic rats showed significant increase in blood urea nitrogen (P<0.001), creatinine & phosphorus (P<0.05) and also significant increase in SGOT, SGPT & ALP levels in serum, which were prevented by Sheetaprabha treated rats in protective groups and decreased in curative groups. Histopathologies of kidneys were prevented calcium oxalate formation and tubular degeneration, and increase in tubular regeneration was observed in protective (130mg/kg, 260mg/kg) group.Conclusion:The present study findings indicate that treatment with Sheetaprabha tablets, which decreases and also prevents the growth of the calcium oxalate crystals in urinary tract. It also seems that the preventive effect is more effective than its curative effect. Hence, this study confirms the traditional use of Sheetaprabha tablets in urolithiasis.
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